Effects of benzodiazepines on immunodeficiency and resistance in mice
| Autor: | S. Mattera, Immacolata Nuzzo, C.Romano Carratelli, R. Ianniello, Ciro Capasso, C. Bentivoglio, Marilena Galdiero, C. Nazzaro, Francesco Galdiero |
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| Přispěvatelé: | Galdiero, F., Bentivoglioc, Nuzzo, I., Ianniello, R., Capasso, C., Mattera, S., Nazzaro, C., Galdiero, Massimiliano, ROMANO CARRATELLI, C. |
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Neutrophils medicine.drug_class T-Lymphocytes Phagocytosis Bacteremia Biology Lymphocyte Activation Monocytes General Biochemistry Genetics and Molecular Biology Benzodiazepines Mice Immunity Internal medicine Cell Adhesion medicine Animal mortality Animals General Pharmacology Toxicology and Pharmaceutics Immunodeficiency B-Lymphocytes Mice Inbred BALB C Salmonella Infections Animal Benzodiazepine Diazepam Immunologic Deficiency Syndromes Antibody titer Chemotaxis General Medicine medicine.disease Survival Rate Chemotaxis Leukocyte Endocrinology Anti-Anxiety Agents Antibody Formation Immunology Cytokines medicine.drug |
| Zdroj: | Life Sciences. 57:2413-2423 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(95)02199-0 |
| Popis: | Our results indicate that benzodiazepine (Bz) treatment time, greater than 2–3 months, induce a decrease of both specific and nonspecific responses. Mice treated for different times with diazepam or chlordemethyldiazepam showed decreased survival to experimental Salmonella typhimurium infections after three months of treatment. Adherence, expressed as the polymorphonuclear cells (PMN) capacity to attach to nylon wool, was impaired after 7 days of treatment. Longer treatments further increase this impairment. PMN from mice treated with Bz for 90 days also demonstrate on impaired chemotaxis and phagocytosis for Saccharomyces cerevisiae . Monocytes from mice treated for 7 days secreted more IL-1 α then controls; the antibody titer in mice given to prolonged treatment progressively diminished compared to controls. Con A or LPS stimulated lymphocytes showed an increase of H 3 -thymidine incorporation from mice treated for a short time and conversely a decreased incorporation when taken from mice that underwent longer treatments. Benzodiazepines were therefore found to affect PMN chemotaxis and phagocitosis, general immunity and survival of mice to infections. |
| Databáze: | OpenAIRE |
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