Association of somatosensory dysfunction with symptom duration in burning mouth syndrome
| Autor: | Eli Eliav, Noboru Noma, Chisa Hirota, Yoshiki Imamura, Daiki Takanezawa, Kosuke Watanabe, Naohiko Sekine |
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| Rok vydání: | 2018 |
| Předmět: |
Pain Threshold
education Pain Burning Mouth Syndrome Somatosensory system 03 medical and health sciences 0302 clinical medicine Forearm Tongue Tip of the tongue Sensation medicine Humans General Dentistry Pain Measurement business.industry digestive oral and skin physiology 030206 dentistry Burning mouth syndrome Peripheral stomatognathic diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Anesthesia Neuropathic pain Female medicine.symptom business |
| Zdroj: | Clinical oral investigations. 23(9) |
| ISSN: | 1436-3771 |
| Popis: | A standardized battery of quantitative sensory tests developed by the German Research Network on Neuropathic Pain (DFNS) was used to assess the association between somatosensory dysfunction and disease duration in patients with burning mouth syndrome (BMS). The 28 female participants with BMS were classified according to disease duration: ≤ 6 months (subchronic BMS, n = 15) and > 6 months (chronic BMS, n = 13); 29 age- and sex-matched healthy volunteers (control group) were recruited from staff of a dental hospital. The DFNS quantitative sensory testing protocol was applied at the ulnar surface of the right forearm and the tip of the tongue. Values for BMS patients and controls were compared and analyzed. The mechanical detection threshold (MDT) was significantly higher (i.e., loss of sensation) at the tongue tip in the chronic BMS group than in the control group (p = 0.011), whereas mechanical pain sensitivity (MPS) at the forearm was significantly higher (i.e., gain of sensation) in the chronic BMS group than in the control group (Z score = − 2.13 and 1.99, respectively). Multivariate analyses revealed that BMS patients could be discriminated from controls by using pressure pain threshold at the tongue (79.3%) (in the subchronic BMS group) and by MDT and MPS at the tongue tip and MPS at the forearm (96.6 and 89.7%, respectively) (in the chronic BMS group). In BMS patients with long disease duration, MDT showed loss of sensation. Increased MPS suggests that a neuropathic mechanism in the peripheral and central nervous systems is involved in BMS development. |
| Databáze: | OpenAIRE |
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