[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation
| Autor: | Bevan Jones, WR, Cope, Thomas, Passamonti, Luca, Fryer, Timothy, Hong, Young, Aigbirhio, Franklin, Kril, JJ, Forrest, SL, Allinson, K, Coles, Jonathan, Simon Jones, P, Spillantini, Maria, Hodges, O'Brien, John, Rowe, James |
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| Přispěvatelé: | Cope, Thomas [0000-0002-4751-1786], Passamonti, Luca [0000-0002-7937-0615], Aigbirhio, Franklin [0000-0001-9453-5257], Coles, Jonathan [0000-0003-4013-679X], Spillantini, Maria [0000-0002-8544-7332], O'Brien, John [0000-0002-0837-5080], Rowe, James [0000-0001-7216-8679], Apollo - University of Cambridge Repository |
| Rok vydání: | 2017 |
| Předmět: |
Aging
FOS: Clinical medicine Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) 32 Biomedical and Clinical Sciences Neurodegenerative Alzheimer's Disease Brain Disorders Frontotemporal Dementia (FTD) 52 Psychology FOS: Biological sciences 5203 Clinical and Health Psychology 3209 Neurosciences Neurological Genetics Acquired Cognitive Impairment Dementia Alzheimer's Disease Related Dementias (ADRD) |
| DOI: | 10.17863/cam.13266 |
| Popis: | The validation of tau radioligands could improve the diagnosis of frontotemporal lobar degeneration and the assessment of disease-modifying therapies. Here, we demonstrate that binding of the tau radioligand [18F]AV-1451 was significantly abnormal in both magnitude and distribution in a patient with familial frontotemporal dementia due to a MAPT 10 + 16C>T gene mutation, recapitulating the pattern of neuropathology seen in her father. Given the genetic diagnosis and the non-Alzheimer's pathology, these findings suggest that [18F]AV-1451 might be a useful biomarker in primary tauopathies. Largerscale in vivo and post-mortem studies will be needed to assess the technique's specificity. TEC is supported by the Association of British Neurologists and the Patrick Berthoud Charitable Trust. JRH, JK, and SF are supported by funding to Forefront, a collaborative research group dedicated to the study of frontotemporal dementia and motor neuron disease, from the National Health and Medical research Council of Australia program grant (1037746). JBR is supported by the Wellcome Trust (103838). The Cambridge Brain Bank, JPC, WRBJ, MGS, and LP are supported by the Cambridge Biomedical Research Centre. MGS is supported by the UK MRC. |
| Databáze: | OpenAIRE |
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