Development and Validation of a Novel Prognostic Nomogram for CD5-Positive Diffuse Large B-Cell Lymphoma: A Retrospective Multicenter Study in China
| Autor: | Yuqing Miao, Wei Sang, Ling Wang, Chunling Wang, Shuiping Huang, Taigang Zhu, Bingpei Zhang, Weiying Gu, Hao Zhang, Yuye Shi, Fei Wang, Yuhao Xue, Ying Wang, Ziyuan Shen, Tianci Li, Jingjing Ye, Bingzong Li, Chenlu He, Dashan Li, Qinhua Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Hepatosplenomegaly nomogram immune system diseases hemic and lymphatic diseases Internal medicine medicine RC254-282 Original Research validation business.industry CD5-positive Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nomogram medicine.disease Lymphoma Brier score DLBCL Cohort Absolute neutrophil count prognosis CD5 medicine.symptom business Diffuse large B-cell lymphoma |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2021.754180 |
| Popis: | BackgroundCD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) is a rare subtype of DLBCL with invasive clinical features and poor prognosis. Current clinical variables based on prognostic systems for DLBCL are inadequate to accurately stratify the prognosis of CD5+ DLBCL.MethodsA total of 195 CD5+ DLBCL patients were retrospectively recruited from nine centers in Huaihai Lymphoma Working Group. MaxStat analysis was used to identify optimal cutoff points for continuous variables; univariable and multivariable Cox analyses were used for variable selection; Kaplan–Meier curve was used to analyze the value of variables on prognosis; and C-index, Brier score, and decision curve analysis were measured for predicting model performance.ResultsThe derivation and validation cohorts consisted of 131 and 64 patients. Of the whole cohort, median age at diagnosis was 61 years, of whom 100 (51.28%) were males and the 5‐year overall survival rate was 42.1%. MYC, BCL-2, and the coexpression of MYC/BCL-2 could distinguish the survival of CD5+ DLBCL. Multivariable analysis showed that age, IPI, red blood cell count, neutrophil count, MYC expression, and hepatosplenomegaly were independent predictors, and the prognostic nomogram was developed. The C‐index of the nomogram was 0.809 in the derivation and 0.770 in the validation cohort. Decision curve analysis proved that compared with IPI, the specific nomogram showed a better identification in CD5+ DLBCL.ConclusionThe proposed nomogram provided a valuable tool for prognosis prediction in patients with CD5+ DLBCL. |
| Databáze: | OpenAIRE |
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