| Autor: |
Stephen J. Dollery, Janette M. Harro, Taralyn J. Wiggins, Brendan P. Wille, Peter C. Kim, John K. Tobin, Ruth V. Bushnell, Naomi J. P. E. R. Tasker, David A. MacLeod, Gregory J. Tobin |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Vaccines; Volume 10; Issue 6; Pages: 833 |
| ISSN: |
2076-393X |
| DOI: |
10.3390/vaccines10060833 |
| Popis: |
Many microbes of concern to human health remain without vaccines. We have developed a whole-microbe inactivation technology that enables us to rapidly inactivate large quantities of a pathogen while retaining epitopes that were destroyed by previous inactivation methods. The method that we call UVC-MDP inactivation can be used to make whole-cell vaccines with increased potency. We and others are exploring the possibility of using improved irradiation-inactivation technologies to develop whole-cell vaccines for numerous antibiotic-resistant microbes. Here, we apply UVC-MDP to produce candidate MRSA vaccines which we test in a stringent tibia implant model of infection challenged with a virulent MSRA strain. We report high levels of clearance in the model and observe a pattern of protection that correlates with the immunogen protein profile used for vaccination. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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