General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila
| Autor: | Aidan Zecevik, Naotsugu Tsuchiya, Bruno van Swinderen, Felix A. Pollock, Kavan Modi, Roberto N. Muñoz, Angus Leung, Dror Cohen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Computer science media_common.quotation_subject General Physics and Astronomy Contrast (statistics) FOS: Physical sciences Asymmetry Quantitative Biology - Quantitative Methods Arousal 03 medical and health sciences 0302 clinical medicine Anesthesia FOS: Biological sciences Quantitative Biology - Neurons and Cognition Physics - Data Analysis Statistics and Probability Neurons and Cognition (q-bio.NC) Statistical complexity 030217 neurology & neurosurgery Data Analysis Statistics and Probability (physics.data-an) Quantitative Methods (q-bio.QM) 030304 developmental biology media_common |
| Popis: | We apply techniques from the field of computational mechanics to evaluate the statistical complexity of neural recording data from fruit flies. First, we connect statistical complexity to the flies' level of conscious arousal, which is manipulated by general anesthesia (isoflurane). We show that the complexity of even single channel time series data decreases under anesthesia. The observed difference in complexity between the two states of conscious arousal increases as higher orders of temporal correlations are taken into account. We then go on to show that, in addition to reducing complexity, anesthesia also modulates the informational structure between the forward- and reverse-time neural signals. Specifically, using three distinct notions of temporal asymmetry we show that anesthesia reduces temporal asymmetry on information-theoretic and information-geometric grounds. In contrast to prior work, our results show that: (1) Complexity differences can emerge at very short timescales and across broad regions of the fly brain, thus heralding the macroscopic state of anesthesia in a previously unforeseen manner, and (2) that general anesthesia also modulates the temporal asymmetry of neural signals. Together, our results demonstrate that anesthetized brains become both less structured and more reversible. 14 pages, 6 figures. Comments welcome; Added time-reversal analysis, updated discussion, new figures (Fig. 5 & Fig. 6) and Tables (Tab. 1) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|