Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins
| Autor: | Ana Claudia F. Amaral, Deborah Quintanilha Falcão, Silvia Luciane Basso, Jefferson Rocha de A. Silva, Aline de Souza Ramos, Igor A. Rodrigues, José Luiz P. Ferreira |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Copaifera paupera
Article Subject Copaifera Leishmania mexicana Antiprotozoal Agents lcsh:Medicine Sesquiterpene 01 natural sciences General Biochemistry Genetics and Molecular Biology Gas Chromatography-Mass Spectrometry chemistry.chemical_compound parasitic diseases Oleoresin Leishmania infantum Particle Size Medicinal plants IC50 General Immunology and Microbiology biology Traditional medicine 010405 organic chemistry Chemistry Plant Extracts lcsh:R Fabaceae General Medicine biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Nanoparticles Emulsions Sesquiterpenes Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2018 (2018) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2018/9781724 |
| Popis: | Based on the ethnopharmacological evidences about the antileishmanial activity ofCopaiferaspp. oleoresins, the effects of crude extracts and fractions of oleoresin of two specimens fromCopaifera pauperawere evaluated onLeishmania amazonensisandLeishmania infantumstrains. The oleoresin rich inα-copaene (38.8%) exhibited the best activity againstL. amazonensis(IC50= 62.5 μg/mL) and againstL. infantum(IC50= 65.9 μg/mL). The sesquiterpeneα-copaene isolated was tested alone and exhibited high antileishmanial activityin vitrowith IC50values forL. amazonensisandL. infantumof 17.2 and 11.4 μg/mL, respectively. In order to increase antileishmanial activity, nanoemulsions containing copaiba oleoresin andα-copaene were developed and assayed againstL. amazonensisandL. infantumpromastigotes. The nanoemulsion containingα-copaene (NANOCOPAEN) showed the best activity against both species, with IC50of 2.5 and 2.2 μg/mL, respectively. This is the first report about the antileishmanial activity ofα-copaene. |
| Databáze: | OpenAIRE |
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