A Systematic Review and Meta-Analysis of Pharmacogenetic Studies in Patients with Chronic Kidney Disease

Autor: Christos Cholevas, Evangelia Dounousi, Georgios Pissas, Theodoros Eleftheriadis, Theoharis C. Theoharides, Georgios Raptis, Ioannis Stefanidis, Maria Tziastoudi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Nephrology
medicine.medical_specialty
Pharmacogenomic Variants
genetic association
QH301-705.5
Prednisolone
Lupus nephritis
Review
030226 pharmacology & pharmacy
Tacrolimus
Catalysis
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
systematic review
Internal medicine
Azathioprine
medicine
Genetic predisposition
Humans
Renal Insufficiency
Chronic
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Spectroscopy
pharmacogenetics
Polymorphism
Genetic
business.industry
Organic Chemistry
General Medicine
medicine.disease
Pharmacogenomic Testing
Computer Science Applications
Transplantation
meta-analysis
Chemistry
Treatment Outcome
030104 developmental biology
Meta-analysis
Cyclosporine
ITPA
business
Pharmacogenetics
chronic kidney disease
Kidney disease
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 4480, p 4480 (2021)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Chronic kidney disease (CKD) is an important global public health problem due to its high prevalence and morbidity. Although the treatment of nephrology patients has changed considerably, ineffectiveness and side effects of medications represent a major issue. In an effort to elucidate the contribution of genetic variants located in several genes in the response to treatment of patients with CKD, we performed a systematic review and meta-analysis of all available pharmacogenetics studies. The association between genotype distribution and response to medication was examined using the dominant, recessive, and additive inheritance models. Subgroup analysis based on ethnicity was also performed. In total, 29 studies were included in the meta-analysis, which examined the association of 11 genes (16 polymorphisms) with the response to treatment regarding CKD. Among the 29 studies, 18 studies included patients with renal transplantation, 8 involved patients with nephrotic syndrome, and 3 studies included patients with lupus nephritis. The present meta-analysis provides strong evidence for the contribution of variants harbored in the ABCB1, IL-10, ITPA, MIF, and TNF genes that creates some genetic predisposition that reduces effectiveness or is associated with adverse events of medications used in CKD.
Databáze: OpenAIRE
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