Direct measurement of pulse wave propagation in capillaries of the human retina
| Autor: | Andrew Metha, Phillip Bedggood |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Capillary action
Pulse pressure wave Pulse Wave Analysis 01 natural sciences Retina 010309 optics 03 medical and health sciences Optics Optical coherence tomography 0103 physical sciences medicine Pulse wave Humans Pulse wave velocity Aorta 030304 developmental biology Physics 0303 health sciences medicine.diagnostic_test business.industry Blood flow Atomic and Molecular Physics and Optics Scanning laser ophthalmoscopy Capillaries Orders of magnitude (time) business Blood Flow Velocity |
| Zdroj: | Optics letters. 46(18) |
| ISSN: | 1539-4794 |
| Popis: | With each contraction of the heart’s left ventricle, a pulse pressure wave surges into the aorta and propagates throughout the vascular tree. The pulse wave drives blood flow forward. Its passage is complex, but it passes more quickly through non-compliant, or stiff, vessels, providing an important signpost of cardiovascular disease. The transparent media of the eye allow direct and non-invasive measurement of this phenomenon within the microvasculature of neural tissue. However, previous estimates differ over three orders of magnitude. Here, we used high spatiotemporal resolution adaptive optics imaging to directly track the pulse wave within individual retinal capillaries in three human subjects. Across 74 unique capillary segments, pulse wave velocity averaged 6.4 ± 0.5 m m / s e c ( m e a n ± S E M ). There was large variation between vessels; the slowest pulse wave was at most 0.8 mm/sec and the fastest at least 17.6 mm/sec. In 44% of vessels, the pulse wave traveled upstream, in the opposite direction to flow, suggesting wave reflection from downstream collecting junctions. |
| Databáze: | OpenAIRE |
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