Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging
| Autor: | Jan C. C. Borleffs, Irma Vulto, Anne Bregje de Boer, Sigrid A. Otto, Rogier van Gent, Kiki Tesselaar, Taco W. Kuijpers, Frank Miedema, Nienke Vrisekoop, Radjin Steingrover, Jan M. Prins, Tom F.W. Wolfs, José A. M. Borghans, Peter M. Lansdorp, Sibyl P. M. Geelen |
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| Přispěvatelé: | Other departments, AII - Amsterdam institute for Infection and Immunity, Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Pediatric AIDS Adolescent Naive T cell T cell Immunology HIV Infections Biology Lymphocyte Activation T-Lymphocyte Subsets Antiretroviral Therapy Highly Active medicine Humans Immunology and Allergy Child Cd4 t cell Compartment (ship) T-cell receptor Infant Middle Aged Phenotype Antiretroviral therapy CD4 Lymphocyte Count Platelet Endothelial Cell Adhesion Molecule-1 Ki-67 Antigen medicine.anatomical_structure Child Preschool 1 - Taverne HIV-1 |
| Zdroj: | Journal of immunology (Baltimore, Md., 181(2), 1573-1581. American Association of Immunologists Journal of Immunology, 181(2), 1573. American Association of Immunologists |
| ISSN: | 0022-1767 |
| Popis: | It remains uncertain whether full T cell reconstitution can be established in HIV-infected children and adults with long-term sustained virological control by highly active antiretroviral therapy (HAART). In this study, we comprehensively analyzed various phenotypical markers of CD4 T cell recovery. In addition to measuring T cell activation and proliferation markers, CD4 T cell generation and aging of the CD4 T cell compartment were assessed by measuring TCR excision circles and the fraction of CD31-expressing naive CD4 T cells. In all children and in adults with relatively high CD4 T cell counts at start of therapy (>200 cells/μl), total CD4 T cell numbers normalized within 1 year of therapy. After long-term HAART (4.4–9.6 years), naive CD4 T cell counts had normalized in both groups. Although in adults with low baseline CD4 T cell counts ( |
| Databáze: | OpenAIRE |
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