Additional file 2 of Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state

Autor: Ziffert, Isabelle, Kaiser, Anette, Babilon, Stefanie, Mörl, Karin, Beck-Sickinger, Annette G.
Rok vydání: 2020
DOI: 10.6084/m9.figshare.12045687.v1
Popis: Additional file 1: Supporting Results. Figure S1. Internalization behavior of hY2 receptor wild type. Figure S2. Prolongation of the recovery time is insufficient to entirely regain activatability. Figure S3. Y2R activation mainly triggers Ca2+-influx from extracellular compartments and excludes Ca2+ as a limiting factor. Figure S4. Activity of selective NPY receptor analogues tested in SHSY5Y cell line endogenously expressing Y2R. Figure S5. Impact of Ca2+ and PKC on cellular cAMP level.
Databáze: OpenAIRE