Human apolipoprotein A-I and C-III genes reside in the p11 → q13 region of chromosome 11
| Autor: | Glenn N. Gray, S. L. Naylor, S. W. Law, H. B. Brewer, Alan Y. Sakaguchi |
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| Rok vydání: | 1984 |
| Předmět: |
Apolipoprotein B
DNA Recombinant Biophysics Chromosomal translocation Hybrid Cells Biochemistry Mice Complementary DNA Animals Humans Apolipoproteins C Molecular Biology Gene Chromosomes Human 6-12 and X Genetics Apolipoprotein C-III Apolipoprotein A-I biology Nucleic Acid Hybridization Chromosome DNA Cell Biology Molecular biology Apolipoproteins biology.protein lipids (amino acids peptides and proteins) Human genome Chromosome 22 |
| Zdroj: | Biochemical and Biophysical Research Communications. 118:934-942 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(84)91485-2 |
| Popis: | Apolipoprotein (apo) A-I is a major protein of high density lipoproteins (HDL). The gene for apoA-I has been localized to the p11 leads to q13 region of chromosome 11 by filter hybridization analysis of mouse-human hybrid cell cDNAs containing chromosome 11 translocations utilizing a cloned human apoA-I cDNA probe. The known linkage of apoA-I and apoC-III also permitted the simultaneous assignment of the apoC-III gene to the same region on chromosome 11. Comparison with previously established gene linkages on the mouse and human genome suggests that apoA-I + apoC-III may be linked to the esterase A4 and uroporphyrinogen synthase genes which are present on the long arm of human chromosome 11. The localization of the apoA-I + apoC-III genes in the p11----q13 region of chromosome 11 represents a definitive chromosomal assignment of a human apolipoprotein gene, and will now enable more detailed analysis of the geneomic organization and linkages of the apolipoprotein genes. |
| Databáze: | OpenAIRE |
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