| Autor: |
Eduard J. van Beers, Rienk Nieuwland, Bart J. Biemond, Augueste Sturk, Marianne C. L. Schaap, R.J. Berckmans, Frederiek F. van Doormaal, Joost C. M. Meijers |
| Přispěvatelé: |
ACS - Amsterdam Cardiovascular Sciences, Other Research, Laboratory Specialized Diagnostics & Research, CCA -Cancer Center Amsterdam, Laboratory for General Clinical Chemistry, Vascular Medicine, AII - Amsterdam institute for Infection and Immunity, Clinical Haematology, Faculteit der Geneeskunde |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Haematologica, 94(11), 1513-1519. Ferrata Storti Foundation |
| ISSN: |
0390-6078 |
| Popis: |
Background: Sickle cell disease is characterized by a hypercoagulable state as a result of multiple factors, including chronic hemolysis and circulating cell-derived microparticles. There is still no consensus on the cellular origin of such microparticles and the exact mechanism by which they may enhance coagulation activation in sickle cell disease.Design and Methods: In the present study, we analyzed the origin of circulating microparticles and their procoagulant phenotype during painful crises and steady state in 25 consecutive patients with sickle cell disease.Results: The majority of microparticles originated from platelets (GPIIIa,CD61) and erythrocytes (glycophorin A,CD235), and their numbers did not differ significantly between crisis and steady state. Erythrocyte-derived microparticles strongly correlated with plasma levels of markers of hemolysis, i.e. hemoglobin (r=-0.58, p0.05). The extent of factor XI inhibition was associated with erythrocyte-derived microparticles (r=0.50, p=0.023).Conclusions: We conclude that the procoagulant state in sickle cell disease is partially explained by the factor XI-dependent procoagulant properties of circulating erythrocyte-derived microparticles. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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