Features of odontogenesis and expression of cytokeratins and tenascin-C in three cases of extraosseous and intraosseous calcifying odontogenic cyst
| Autor: | Luciano Zardi, Jarkko Hietanen, Giorgio Allemanni, Pirjo-Liisa Lukinmaa, Anu Leppäniemi |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent Gingiva Connective tissue Stratified squamous epithelium Biology Epithelium Pathology and Forensic Medicine 03 medical and health sciences Calcifying odontogenic cyst Cytokeratin 0302 clinical medicine Odontogenic cyst medicine Humans Cell Lineage Cyst Child Coloring Agents Alveolar mucosa Aged Glycoproteins 030304 developmental biology Radicular Cyst 0303 health sciences Mouth Mucosa Antibodies Monoclonal Tenascin 030206 dentistry Anatomy Odontogenic Cyst Calcifying medicine.disease Immunohistochemistry Gene Expression Regulation Neoplastic Mandibular Neoplasms medicine.anatomical_structure Otorhinolaryngology Connective Tissue Keratins Odontogenesis Periodontics Female Mouth Neoplasms Oral Surgery |
| Zdroj: | Journal of Oral Pathology and Medicine. 26:265-272 |
| ISSN: | 1600-0714 0904-2512 |
| Popis: | To characterize further the nature of calcifying odontogenic cyst (COC), we studied histologically and immunohistochemically an extraosseous and two intraosseous lesions. The extraosseous COC was in continuity with the stratified squamous epithelium of the alveolar mucosa. Immunostaining with monoclonal antibodies showed reactivity of both low- and high-molecular-weight cytokeratins, the degree of coexpression decreasing with the increasing morphological diversity of the cyst/tumour epithelium. Staining for the matrix glycoprotein tenascin-C was seen not only in the connective tissue, where its distribution patterns corresponded to the stage of hard tissue formation, but also in epithelial elements. The staining patterns were analogous to those described during normal tooth formation. Both the morphological characteristics and expression patterns of the various cytokeratin types and tenascin-C implied that COC represents a pathological counterpart of normal odontogenesis. In the case of the extraosseous COC, the correspondence could be traced back to early stages of tooth development. |
| Databáze: | OpenAIRE |
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