Minimal clinically important difference for the rhinoconjunctivitis quality of life questionnaire in allergic rhinitis in Thai population
| Autor: | Watcharee Lermankul, Pennapha Saisombat, Bangon Pinkaew, Pacharaporn Phonpornpaiboon, Pongsakorn Tantilipikorn, Chaweewan Bunnag |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Quality of life
medicine.medical_specialty Dermatology Thai population Symptoms score Allergic rhinitis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Immunology and Allergy Medicine Clinical significance Prospective cohort study Rhinoconjunctivitis Quality of Life (Rcq-36) questionnaire business.industry Minimal clinically important difference Chronic rhinitis humanities Treatment efficacy 030228 respiratory system Original Article business |
| Zdroj: | Asia Pacific Allergy |
| ISSN: | 2233-8276 |
| DOI: | 10.5415/apallergy.2019.9.e6 |
| Popis: | Background Clinical measurement of the severity of allergic rhinitis (AR) can be assessed by symptoms score and patient quality of life (QoL). The magnitude of change in both symptoms and patient QoL should be considered in the management of AR. Objective The aim of this study was to determine the minimal clinically important difference (MCID) in AR in Thai population. Methods This prospective study recruited AR patients that attended our clinic during September 2011 to February 2012. The Rhinoconjunctivitis Quality of Life (Rcq-36) questionnaire was used to evaluate patient QoL. The Global Rating of Change Scale (GRCS) was used to assess improvement or deterioration in condition. The MCID was determined using an anchor-based method based on the GRCS, which was compared to the MCID determined by a distribution-based method based on the standard deviation (SD). Results Three hundred seventy-two patients with chronic rhinitis were recruited. Eighty-four of those had positive skin prick test and be diagnosed as AR. Of those, 79 completed the study and were included in the final analysis. A change of 2 points on the GRCS yielded an MCID for overall QoL of 0.21 ± 0.57. When applying the distribution-based method, an SD of 1.5 SD yielded an MCID for QoL of 0.27. For the rhinitis symptoms domain, the MCID was 0.42 ± 0.72. Conclusions The MCID for overall QoL and rhinitis symptoms in Thai AR patients was found to be 0.21 ± 0.57 and 0.42 ± 0.72, respectively. MCID can be applied for determining the clinical significance of treatment efficacy in AR. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|