Sequence effect in the treatment of proliferative diabetic retinopathy with intravitreal ranibizumab and panretinal photocoagulation
| Autor: | Chenghu Wang, Xiangzhong Xu, Shu Zhang, Guofan Cao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty genetic structures Visual Acuity Angiogenesis Inhibitors Treatment sequence Panretinal photocoagulation Retina 03 medical and health sciences 0302 clinical medicine Clinical Protocols Ophthalmology Ranibizumab medicine Humans Fluorescein Angiography Sequence (medicine) Retrospective Studies Diabetic Retinopathy Laser Coagulation business.industry General Medicine Diabetic retinopathy Middle Aged medicine.disease Combined Modality Therapy Treatment Outcome Intravitreal Injections 030221 ophthalmology & optometry Female Intravitreal ranibizumab business 030217 neurology & neurosurgery Tomography Optical Coherence |
| Zdroj: | European journal of ophthalmology. 30(1) |
| ISSN: | 1724-6016 |
| Popis: | Purpose: To compare the outcome of the sequence in the two treatments (intravitreal ranibizumab and panretinal photocoagulation) in high-risk proliferative diabetic retinopathy. Methods: This retrospective study included 35 patients with newly diagnosed high-risk proliferative diabetic retinopathy in 43 eyes; 18 (22 eyes) received intravitreal ranibizumab before panretinal photocoagulation (intravitreal ranibizumab+ group), while the other 17 (21 eyes) received panretinal photocoagulation before intravitreal ranibizumab (panretinal photocoagulation+ group). Each subject received three intravitreal ranibizumabs that were interleaved with three panretinal photocoagulations. The first treatment (either intravitreal ranibizumab or panretinal photocoagulation) was done 1 week before the second one. The interval between intravitreal ranibizumabs was 4 weeks, panretinal photocoagulation was 2 weeks. The power and pulse duration were determined based upon the status of each retinal spot before each panretinal photocoagulation. The retinal non-perfusion region was measured with fundus fluorescein angiography before and 1 month after the final treatment. The central macular thickness was measured with optical coherence tomography within 1 week before the first treatment, before each panretinal photocoagulation, and 1 month after the final intravitreal ranibizumab. Results: The panretinal photocoagulation energy required for effective treatment was lower in intravitreal ranibizumab+ group in the first and second sessions and in total energy (p Conclusion: The sequence used in intravitreal ranibizumab+ group showed clear advantages over that in panretinal photocoagulation+ group in the treatment of proliferative diabetic retinopathy, not only in the use of lower energy for panretinal photocoagulation but also in the more rapid regression of neovascularization and less need of additional treatment. |
| Databáze: | OpenAIRE |
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