Comparative therapeutic use of Risedronate and Calcarea phosphorica - Allopathy versus homeopathy - In bone repair in castrated rats
| Autor: | Cristina Werkman, Giselle Segnini Senra, Rosilene Fernandes da Rocha, Adriana Aigotti Haberbeck Brandão |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Calcium Phosphates
Male Bone density Osteoporosis Dentistry Calcarea phosphorica Fracture healing orchiectomy Bone remodeling calcium phosphate plant medicinal product Bone Density General Materials Science animal rat bone density conservation agent Bone Density Conservation Agents drug effect Sham surgery Etidronic Acid Homeopathy risedronic acid Risedronic acid Bone Remodeling Risedronic Acid medicine.drug medicine.medical_specialty analysis of variance Allopathy Bone healing medicine Animals bone remodeling Analysis of Variance business.industry disease model phytotherapy Etidronic acid medicine.disease osteoporosis Surgery Rats Disease Models Animal drug derivative pathology Plant Preparations business Orchiectomy Phytotherapy |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Brazilian Oral Research v.20 n.3 2006 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
| Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:21:54Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:45:40Z : No. of bitstreams: 1 2-s2.0-33750352951.pdf: 302435 bytes, checksum: 9dd170a2e7494bf029425ca2d8c5c589 (MD5) Made available in DSpace on 2014-05-27T11:21:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-07-01 Osteoporosis, a disease characterized by progressive bone loss, has been the target of several studies in the past few years. It results in a much higher risk for fractures and might cause slower bone lesion healing. The aim of this work was to study the effects of Risedronate (allopathic medicine) and Calcarea phosphorica 6CH (homeopathic medicine) on the repair of bone lesions in male rats with osteoporosis induced by castration. Eighty-four three-month-old rats were used divided into four groups of twenty-one animals each. Three groups where castrated and one group was submitted to Sham surgery. One month later, cortical lesions were made in all animals' tibiae and, after one day, the different experimental treatments began according to the following groups: CR - castrated/Risedronate (1 mg/kg/day); CCp - castrated/ Calcarea phosphorica 6CH (3 drops/day); CP - castrated/placebo and SP - Sham/placebo. The animals were sacrificed at seven, fourteen and twenty-eight days after the beginning of the treatments and had their tibiae removed. Digital radiographs of the tibiae were taken and analyzed in order to evaluate the optical density of the defect area. Then, they were decalcified and processed for histological and histomorphometrical analysis. The data were submitted to ANOVA, and to the Tukey and Dunnett tests (5%). The allopathic and homeopathic treatments led to different bone formation as regards remodeling and maturation aspects. Further research is necessary to access the resistance and quality of the newly formed bone. Department of Biosciences and Oral Diagnosis School of Dentistry of São José dos Campos São Paulo State University, São Paulo Department of Biosciences and Oral Diagnosis School of Dentistry of São José dos Campos São Paulo State University, São Paulo |
| Databáze: | OpenAIRE |
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