Metabolic markers and oxidative stress in children’s obesity pathogenesis
| Autor: | O. V. Povarova, E. A. Gorodetskaya, E. I. Kalenikova, O. S. Medvedev |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty children obesity oxidative stress q10 coenzyme non-alcoholic fatty liver disease insulin resistance adipokines Adipose tissue Adipokine 030209 endocrinology & metabolism Inflammation Mitochondrion medicine.disease_cause Pediatrics RJ1-570 Pathogenesis 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine medicine Endothelial dysfunction business.industry medicine.disease 030104 developmental biology Endocrinology Pediatrics Perinatology and Child Health medicine.symptom business Oxidative stress |
| Zdroj: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 65, Iss 1, Pp 22-29 (2020) |
| ISSN: | 2500-2228 1027-4065 |
| DOI: | 10.21508/1027-4065-2020-65-1-22-29 |
| Popis: | The article presents a modern view of obesity as a chronic inflammation of adipose tissue. Obesity is accompanied by metabolic changes in lipid, protein, carbohydrate, mineral metabolism and disorders in the hormonal function of adipose tissue as an endo- and paracrine organ. At the moment, there are searched the biochemical markers of metabolic disorders of obesity. The obesity-related factors (hyperglycemia, increased lipid levels, insulin resistance, chronic inflammation, hyperleptinemia, endothelial dysfunction, impaired respiratory function of mitochondria, minerals and microelements deficiency) form and increase oxidative stress making it an integral component of the pathogenesis of obesity and possible complications. Given the important role of Q10 coenzyme in antioxidant tissue protection, the authors discuss the relationship of obesity and metabolic disorders to the endogenous levels of Q10 coenzyme and its possible use for pharmacological correction. |
| Databáze: | OpenAIRE |
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