Selective Contribution of Regional Adiposity, Skeletal Muscle, and Adipokines to Glucose Disposal in Older Adults
Autor: | Chee Wai Chia, Luigi Ferrucci, Ramona Ramachandran, Josephine M. Egan, E. Jeffrey Metter, Kristofer S. Gravenstein |
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Rok vydání: | 2012 |
Předmět: |
Blood Glucose
Male Aging medicine.medical_specialty Waist Adipokine Article Body Mass Index Adipokines Internal medicine Glucose Intolerance medicine Humans Muscle Skeletal Geriatric Assessment Adiposity Aged Retrospective Studies Aged 80 and over Glucose tolerance test Adiponectin medicine.diagnostic_test business.industry Incidence Leptin Area under the curve Skeletal muscle Glucose Tolerance Test Middle Aged Cross-Sectional Studies Endocrinology medicine.anatomical_structure Adipose Tissue Baltimore Female Geriatrics and Gerontology Tomography X-Ray Computed business Body mass index Follow-Up Studies |
Zdroj: | Journal of the American Geriatrics Society. 60:707-712 |
ISSN: | 0002-8614 |
Popis: | Objectives: to study the relationships between muscle mass, regional adiposity, and adipokines and glucose disposal in an older population. Design: Cross-sectional analysis. Setting: Community-dwelling volunteers from the Baltimore Longitudinal Study of Aging. Participants: Two hundred eighty men and 259 women with a mean age of 71.1 ± 0.4 (range 55�96) and complete data on fasting plasma adiponectin and leptin, oral glucose tolerance test (OGTT) (plasma glucose available at 0, 20, 40, 60, 80, 100, and 120 minutes), thigh computed tomography (CT), physical activity levels, and anthropometric measures. Measurements: Participants were classified into eight groups according to the presence of global adiposity (body mass index > 27 kg/m2), central adiposity (waist circumference > 88 cm for women and > 102 cm for men), and low muscle mass (CT thigh, lowest sex-specific tertile (93.8 cm2 in women and 110.7 cm2 in men) of adjusted thigh muscle area). Linear regression models were used to estimate the contribution of these eight groups to early glucose area under the curve (AUC) (t = 0�40 minutes), late glucose AUC (t = 60�120 minutes), and total glucose AUC (t = 0�120 minutes) from the OGTT. Results: Regardless of muscle mass, individuals with a combination of central and global adiposity were more likely to have delayed glucose disposal rates (P < .05). A strong negative association was also found between circulating adiponectin levels and glucose disposal rates (early AUC, ? = -0.14; late AUC, ? = -0.20; and total AUC, ? = -0.20; P < .05 for all three AUCs) after adjusting for regional adiposity, muscle mass, circulating leptin levels, physical activity, age, and sex. Conclusion: Older individuals with global and central adiposity may be at risk of glucose intolerance unrelated to low muscle mass |
Databáze: | OpenAIRE |
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