Prevalence of angiotensin-converting enzyme, methylenetetrahydrofolate reductase, Factor V Leiden, prothrombin and apolipoprotein E gene polymorphisms in Morocco

Autor:	Sellama Nadifi, Mohamed Taha Moutawafik, Mariame El Messal, Hanane Bellayou, Thierry Paluku They-They, Khalil Hamzi
Rok vydání:	2010
Předmět:	Genetic Markers Aging Homocysteine Genotype Physiology Epidemiology Biology Peptidyl-Dipeptidase A Polymerase Chain Reaction chemistry.chemical_compound Apolipoproteins E Gene Frequency Polymorphism (computer science) Risk Factors Genetics Factor V Leiden medicine Ethnicity Humans Genetic Predisposition to Disease Genetic Testing Allele Allele frequency Genotyping Methylenetetrahydrofolate Reductase (NADPH2) Polymorphism Genetic Public Health Environmental and Occupational Health Factor V Angiotensin-converting enzyme medicine.disease Arabs Morocco Cross-Sectional Studies chemistry Cardiovascular Diseases Methylenetetrahydrofolate reductase biology.protein Prothrombin
Zdroj:	Annals of human biology. 37(6)
ISSN:	1464-5033
Popis:	Evidence of the influence of genetic risk factors on cardiovascular diseases is more or less established. These genetic factors are involved in several pathways affecting blood pressure regulation, blood coagulation, homocysteine and lipid metabolisms.We evaluated frequencies of five genetic polymorphisms to assess their informativeness as markers for prospective clinical studies.182 healthy Moroccan subjects were genotyped for ACE I/D by amplification alone and by amplification followed by enzymatic digestion for other polymorphisms.Allele frequencies of ACE ID, MTHFR C677T were 76.6%, 26.9% for D and T alleles, respectively. APOE polymorphism showed 11.3%, 78.6% and 10.2% for the alleles E2, E3 and E4, respectively. The frequency for FII G20210A polymorphism was around 2.7% for A allele. Our data showed an absence of FVL mutation. Using allele frequencies, genetic distances between Moroccan and other populations revealed an independent variability of these polymorphisms.These values appear to be influenced by findings in European and African peoples, and may be considered in assessing the clinical significance of a predisposition to cardiovascular disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1cc3c27398f4fd1bf1dc1ce1e71425 https://pubmed.ncbi.nlm.nih.gov/20687780 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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