Acute spontaneous tumor lysis syndrome as the initial presentation of ALK-positive diffuse large B-cell lymphoma
| Autor: | Jose Sandoval, Clifford Blieden, Jennifer R. Chapman-Fredricks, Vinicius Ernani, Offiong F Ikpatt |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Histology Antineoplastic Agents Disease Pathology and Forensic Medicine Fatal Outcome immune system diseases hemic and lymphatic diseases Biomarkers Tumor Medicine Neoplasm Anaplastic lymphoma kinase Humans Anaplastic Lymphoma Kinase Obesity business.industry Receptor Protein-Tyrosine Kinases medicine.disease BCL10 Lymphoma Tumor lysis syndrome Medical Laboratory Technology Cancer research Immunohistochemistry Lymphoma Large B-Cell Diffuse business Tumor Lysis Syndrome Diffuse large B-cell lymphoma |
| Zdroj: | Applied immunohistochemistrymolecular morphology : AIMM. 22(4) |
| ISSN: | 1533-4058 |
| Popis: | Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma (DLBCL) is a recently described, uncommon form of DLBCL, which has been seen primarily in young men and which presents with advanced disease. The fact that ALK-positive DLBCL is an uncommon diagnosis is likely due to the combined effects of this being an uncommon disease coupled with the challenges in the pathologic identification of this neoplasm. Prompt and accurate identification of this tumor is becoming increasingly important, however, as we enter the era of therapeutic ALK inhibitors, which are currently undergoing study in several clinical trials. Here, we report a case of ALK-positive DLBCL in a 39-year-old male patient who presented with spontaneous tumor lysis syndrome. We review the clinical, morphologic, immunohistochemical, and molecular aspects of this case and of ALK-positive DLBCL in general, with the purpose of bringing to light the existence of this disease and its potential future therapy. |
| Databáze: | OpenAIRE |
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