Oestrogen induced hypertriglyceridaemia: role of the adrenal cortex
| Autor: | N. Vydelingum, A. H. Kissebah, T. R. Fraser, Afolabi Sk, B. R. Tulloch |
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| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Hyperlipidemias chemistry.chemical_compound Endocrinology Corticosterone Adrenal Cortex Hormones Internal medicine Hyperlipidemia Adrenal Glands medicine Animals Triglycerides chemistry.chemical_classification Adrenal cortex business.industry Adrenalectomy Acetyl-CoA carboxylase Fatty acid Estrogens medicine.disease Rats medicine.anatomical_structure chemistry Liver Lipogenesis Adrenal Cortex Female Fatty Acid Synthases business Homeostasis Acetyl-CoA Carboxylase |
| Zdroj: | Clinical endocrinology. 5(3) |
| ISSN: | 0300-0664 |
| Popis: | The role of the adrenal cortex in the pathogenesis of hypertriglyceridaemia associated with the intake of oral contraceptive agents containing oestrogen has been investigated in rats. Bilateral adrenalectomy reduced the activity of hepatic enzymes regulating lipogenesis (acetyl CoA carboxylase, fatty acid synthetase) and decreased plasma triglyceride concentrations. On the other hand, the administration of high dosage corticosterone induced the activity of hepatic enzymes with consequent elevation in serum triglyceride levels. In animals with intact adrenals the administration of oestradiol: (a) raised plasma triglyceride levels, (b) enhanced the activity of hepatic enzymes, and (c) increased the adrenal cortex:body weight ratio. The effects (a) and (b) were not observed when both adrenals were removed prior to oestrogen therapy. High dosage corticosterone replacement was found to be essential for the oestradiol to produce its effects on hepatic enzymes and plasma triglyceride levels. The results suggest a regulatory role for the adrenal cortex in the homeostasis of plasma triglyceride concentration and that the hypertriglyceridaemia induced by the oestrogen containing preparations might be secondary to alterations in adrenocortical function. |
| Databáze: | OpenAIRE |
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