Vulvar intraepithelial neoplasia
| Autor: | Berta Díaz-Feijoo, Jose Luis Sánchez-Iglesias, Assumpció Pérez-Benavente, Silvia Cabrera, Melissa Bradbury, Silvia Franco-Camps, Cristina Centeno-Mediavilla, Angel García-Jiménez, Antonio Gil-Moreno |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Multivariate analysis Adolescent Immunology HIV Infections Disease Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Immunology and Allergy Medicine Young adult Survival analysis Aged Retrospective Studies Aged 80 and over Univariate analysis 030219 obstetrics & reproductive medicine Vulvar Neoplasms business.industry Retrospective cohort study Middle Aged Vulvar intraepithelial neoplasia medicine.disease Survival Analysis Surgery Treatment Outcome Infectious Diseases 030220 oncology & carcinogenesis Female business Carcinoma in Situ Cohort study |
| Zdroj: | AIDS. 30:859-868 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/qad.0000000000000984 |
| Popis: | OBJECTIVE Immunocompromised patients are at increased risk of developing preinvasive lesions of the lower genital tract. There are a limited number of studies on vulvar intraepithelial neoplasia (VIN) in HIV-positive women. We aimed to review the clinical presentation of VIN, management and survival outcomes in this group of patients. DESIGN Observational cohort study. METHODS Data was collected from women diagnosed with VIN at the Hospital Vall d'Hebron between September 1994 and October 2011. The main outcome measures were recurrence-free survival (RFS) and progression-free survival (PFS). Risk factors for recurrence and progression were assessed using univariate and multivariate analyses. RESULTS Thirty-seven out of 107 women were HIV positive (34.6%). The median follow-up time was 32 (range 12-179) months. Compared with the HIV-negative group, HIV-positive women were younger (median age 37 vs. 44 years, P = 0.003) and presented with multifocal and multicentric disease more frequently (63.6 vs. 22.2% and 84.8 vs. 43.3%, respectively, P |
| Databáze: | OpenAIRE |
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