Reference intervals for serum 1,5-anhydroglucitol in children, adolescents, adults, and pregnant women
| Autor: | Geraldo Picheth, Aline Borsato Hauser, Mauren Isfer Anghebem-Oliveira, Railson Henneberg, Fabiane Gomes de Moraes Rego, Marciane Welter, Kátia Cristina Boritza |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Clinical Biochemistry 030209 endocrinology & metabolism Deoxyglucose Biochemistry Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy medicine Humans Young adult Child Glycemic business.industry Obstetrics Biochemistry (medical) Infant Newborn Healthy subjects Infant General Medicine medicine.disease Reference intervals 030104 developmental biology chemistry Child Preschool Early adolescents Gestation 1 5-Anhydroglucitol Female business Biomarkers |
| Zdroj: | Clinica Chimica Acta. 486:54-58 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2018.07.018 |
| Popis: | 1,5-anhydroglucitol (1,5-AG) is a validated marker of short-term glycemic control. We determined the reference intervals of 1,5-AG in different age groups and during pregnancy.Blood samples were collected from 2303 Euro-Brazilian healthy subjects: 580 children, 496 adolescents, 922 adults matched by age and sex, and 305 pregnant women in four gestational periods. Serum 1,5-AG was measured using an enzymatic reagent in an automated system.The calculated reference intervals (nonparametric, 2.5th-97.5th) for males and females were, respectively: children, 96-302 and 89-277 μmol/l; adolescents, 84-311 and 79-277 μmol/l; and adults, 80-260 and 62-241 μmol/l. Males consistently showed significantly higher concentrations than females. 1,5-AG reference intervals in pregnant women were 56-298 μmol/l at23 weeks gestation (n = 110), 37-166 μmol/l at 24-28 weeks gestation (n = 106), 34-155 μmol/l at 29-32 weeks gestation (n = 52), and 33-246 μmol/l at32 weeks gestation (n = 37). No significant differences in 1,5-AG concentration were observed between non-pregnant and pregnant women at23 weeks of gestation. A negative correlation (r = -0.287; p .001) between 1,5-AG concentration and age was observed.The reference intervals for 1,5-AG were affected by sex and age. |
| Databáze: | OpenAIRE |
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