Ruthenium(ii ) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy
| Autor: | Marie Maynadier, Vanja Stojanovic, Alain Morère, Marcel Garcia, Jean-Olivier Durand, Elise Bouffard, Frédérique Cunin, Nikola Ž. Knežević, Gilles Lemercier, Khaled El Cheikh, Magali Gary-Bobo, Arnaud Chaix |
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| Přispěvatelé: | Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging medicine.medical_treatment Biomedical Engineering Nanoparticle chemistry.chemical_element Photodynamic therapy [CHIM.THER]Chemical Sciences/Medicinal Chemistry 02 engineering and technology Polyethylene glycol 010402 general chemistry Porous silicon Photochemistry 01 natural sciences chemistry.chemical_compound Two-photon excitation microscopy medicine Moiety [CHIM.COOR]Chemical Sciences/Coordination chemistry General Materials Science technology industry and agriculture General Chemistry General Medicine equipment and supplies 021001 nanoscience & nanotechnology 0104 chemical sciences 3. Good health Ruthenium chemistry Nanocarriers 0210 nano-technology |
| Zdroj: | Journal of materials chemistry B Journal of materials chemistry B, Royal Society of Chemistry, 2016, 4 (7), pp.1337-1342. ⟨10.1039/C5TB02726H⟩ |
| ISSN: | 2050-7518 2050-750X |
| Popis: | International audience; Multifunctionalized porous silicon nanoparticles (pSiNP) containing novel Ru(II) complex-photosensitizer, polyethylene glycol moiety, and mannose molecules as cancer targeting ligands, are constructed and showcased for application in near infrared (NIR) light-responsive photodynamic therapy (PDT) and imaging of cancer. Exposure to NIR light leads to twophoton excitation of the Ru(II)-complex which allows efficient simultaneous cancer-imaging and targeted PDT therapy with the functionalized biodegradable pSiNP nanocarriers. |
| Databáze: | OpenAIRE |
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