Effective Anti-TNF-α Therapy Can Induce Rapid Resolution and Sustained Decrease of Gastroduodenal Mucosal Amyloid Deposits in Reactive Amyloidosis Associated with Rheumatoid Arthritis
| Autor: | Masaaki Nakano, Daisuke Kobayashi, Takehito Sakai, Shintaro Hirose, Takeshi Kuroda, Shuichi Murakami, Ichiei Narita, Yoko Wada, Takako Saeki, Naohito Tanabe |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Amyloid medicine.medical_specialty Pathology Duodenum Immunology Anti-Inflammatory Agents Arthritis Gastroenterology Receptors Tumor Necrosis Factor Etanercept Arthritis Rheumatoid Young Adult Gastrointestinal Agents Rheumatology AA amyloidosis Internal medicine Biopsy medicine Humans Immunology and Allergy Intestinal Mucosa Serum Amyloid A Protein Aged medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Amyloidosis Antibodies Monoclonal Middle Aged medicine.disease Infliximab Gastric Mucosa Immunoglobulin G Rheumatoid arthritis Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | The Journal of Rheumatology. 36:2409-2415 |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.090101 |
| Popis: | Objective.To examine the effect of anti-tumor necrosis factor-α (anti-TNF) therapy in patients with reactive AA amyloidosis associated with rheumatoid arthritis (RA).Methods.Fourteen patients with reactive AA amyloidosis associated with RA were prospectively evaluated. Four patients were treated with infliximab and 10 with etanercept. The mean period of anti-TNF therapy was 20.1 ± 13.8 months. Laboratory findings and renal function were examined before and after initiation of anti-TNF therapy. In 9 patients the area of amyloid deposits in serial gastroduodenal mucosal biopsy specimens was examined and image analysis was performed.Results.C-reactive protein and serum amyloid A protein levels were significantly reduced after initiation of anti-TNF therapy. Twenty-four hour creatinine clearance improved in 4 patients, did not change in 5, and deteriorated in 3. Twenty-four hour urinary protein excretion was significantly decreased in 3 patients, not exacerbated in 6, and increased in 3 after initiation of anti-TNF therapy. The biopsy specimens from the 9 patients who underwent serial gastroduodenal biopsies showed significant decreases in the area of amyloid deposits, from 8.8% ± 6.4% to 1.6% ± 0.6% (p = 0.003) after initiation of anti-TNF therapy. Four patients showed a sustained decrease in the areas of amyloid deposits in their third biopsy specimens, and amyloid deposits were not detectable in 2.Conclusion.Our results indicate a striking effect of anti-TNF therapy for rapid removal and sustained disappearance of amyloid deposits in gastric mucosal tissue with amelioration of renal functions in patients with reactive amyloidosis due to RA. |
| Databáze: | OpenAIRE |
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