Telomeres and telomerase in the clinical management of colorectal cancer
| Autor: | J. Viñas-Salas, C. Valls-Bautista, C. Piñol-Felis, T. Fernández-Marcelo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Senescence Cancer Research Telomerase Colorectal cancer Cell 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor Humans Medicine Diagnostic biomarker business.industry Cancer Diagnostic marker General Medicine Telomere medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunology Cancer research Colorectal Neoplasms business |
| Zdroj: | Clinical and Translational Oncology. 19:399-408 |
| ISSN: | 1699-3055 1699-048X |
| DOI: | 10.1007/s12094-016-1559-0 |
| Popis: | Colorectal cancer (CRC) is the third most common cancer worldwide. Our aim is to describe the state of the art about the role of telomeres and telomerase in the clinical management of CRC and its potential utility as prognostic and diagnostic biomarkers and targets of new treatments. Telomere length could be a new diagnostic marker as an anomalous behavior is observed in peripheral blood cells when CRC patients and healthy people are compared. Moreover, telomeres and telomerase may be used as diagnostic markers considering that universal changes appear along the CRC process. Currently, new therapeutic cancer approaches are focused on inhibiting the maintenance of telomere length, choosing as targets telomerase -or its subunits- or the Shelterin complex. The goal of these therapies is the shortening of telomeres and the induction of cell senescence. Telomeres and telomerase emerge as useful molecular tools in the clinical management of CRC. |
| Databáze: | OpenAIRE |
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