Zoledronate-responsive calcitriol-mediated hypercalcemia in a 5-year-old case with squamous cell carcinoma on the background of xeroderma pigmentosum
| Autor: | Gül Yeşiltepe Mutlu, Hülya Kayserili, Banu Oflaz Sözmen, Esra Börklü Yücel, Ulkem Colak, Şükrü Hatun |
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| Přispěvatelé: | Mutlu, Gül Yeşiltepe (ORCID 0000-0003-3919-7763 & YÖK ID 153511), Hatun, Şükrü (ORCID 0000-0003-1633-9570 & YÖK ID 153504), Çolak, Ülkem, Sözmen, Banu Oflaz, Yücel, Esra B., Karabey, Hülya Kayserili (ORCID 0000-0003-0376-499X & YÖK ID 7945), Koç University Hospital, School of Medicine, Department of Medical Genetics, Department of Pediatrics, Department of Pediatrics Endocrinology, Department of Pediatrics Hematology Oncology |
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Xeroderma pigmentosum Calcitriol Endocrinology Diabetes and Metabolism Medicine Endocrinology and metabolism Pediatrics Malignancy 03 medical and health sciences 0302 clinical medicine Endocrinology polycyclic compounds Basal cell Secretion Adult patients business.industry nutritional and metabolic diseases medicine.disease 030104 developmental biology Zoledronic acid Hypercalcemia 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Cancer research lipids (amino acids peptides and proteins) Squamous Cell Skin Carcinoma business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2019-0158 |
| Popis: | Malignancy-induced hypercalcemia is a very rare condition in children whereas it is more common among adult patients with malignancy. The mechanisms of malignancy-induced hypercalcemia include the over-secretion of parathyroid hormone-related protein (PTHrP), osteolytic metastases and the over-production of 1,25-dihydroxyvitamin D (calcitriol). Although hypercalcemia due to PTHrP secretion has been published before, overproduction of calcitriol has not been reported yet in pediatric squamous cell skin carcinoma cases. Herein, we report calcitriol-mediated severe hypercalcemia in a 5-year-old boy with squamous cell skin carcinoma arising in the background of xeroderma pigmentosum (XP) which responded well to zoledronate treatment. To the best of our knowledge, this is the first pediatric case of malignancy-induced hypercalcemia which is mediated by calcitriol in squamous cell skin carcinoma. NA |
| Databáze: | OpenAIRE |
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