Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects
| Autor: | Thomas Radman, Nicholas L. Balderston, Monique Ernst, Camille Roberts, Sarah H. Lisanby, Emily M. Beydler, Christian Grillon, Bruce Luber, Zhi-De Deng, Tiffany R. Lago |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Anxiety treatments Reflex Startle medicine.medical_treatment Prefrontal Cortex Anxiety Affect (psychology) Amygdala behavioral disciplines and activities 050105 experimental psychology Article Arousal 03 medical and health sciences 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences Pharmacology Cross-Over Studies 05 social sciences Healthy subjects Cognitive neuroscience Magnetic Resonance Imaging Transcranial Magnetic Stimulation Healthy Volunteers Dorsolateral prefrontal cortex Transcranial magnetic stimulation Psychiatry and Mental health medicine.anatomical_structure nervous system Female medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Neuropsychopharmacology |
| ISSN: | 1740-634X 0893-133X |
| Popis: | Much of the mechanistic research on anxiety focuses on subcortical structures such as the amygdala; however, less is known about the distributed cortical circuit that also contributes to anxiety expression. One way to learn about this circuit is to probe candidate regions using transcranial magnetic stimulation (TMS). In this study, we tested the involvement of the dorsolateral prefrontal cortex (dlPFC), in anxiety expression using 10 Hz repetitive TMS (rTMS). In a within-subject, crossover experiment, the study measured anxiety in healthy subjects before and after a session of 10 Hz rTMS to the right dorsolateral prefrontal cortex (dlPFC). It used threat of predictable and unpredictable shock to induce anxiety and anxiety potentiated startle to assess anxiety. Counter to our hypotheses, results showed an increase in anxiety-potentiated startle following active but not sham rTMS. These results suggest a mechanistic link between right dlPFC activity and physiological anxiety expression. This result supports current models of prefrontal asymmetry in affect, and lays the groundwork for further exploration into the cortical mechanisms mediating anxiety, which may lead to novel anxiety treatments. |
| Databáze: | OpenAIRE |
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