Prevalence and management of pain in Italian patients with advanced non-small-cell lung cancer
| Autor: | Ciro Gallo, F. Perrone, Santi Barbera, F. Ferraù, E. Piazza, Luigi Manzione, M. Di Maio, G P Ianniello, Alessandra Bearz, Rosario Vincenz Iaffaioli, Cesare Gridelli, E. Di Salvo, Vincenzo Adamo, Mario Spatafora, L. Brancaccio, L. Isa, Sergio Federico Robbiati, Francesco Rosetti, Francesco Carrozza, Luciano Frontini |
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| Přispěvatelé: | Di Maio, M, Gridelli, C, Gallo, C, Manzione, L, Brancaccio, L, Barbera, S, Robbiati, Sf, Ianniello, Gp, Ferraù, F, Piazza, E, Frontini, L, Rosetti, F, Carrozza, F, Bearz, A, Spatafora, M, Adamo, V, Isa, L, Iaffaioli, Rv, DI SALVO, Enrico, Perrone, F., DI MAIO, M, Gallo, Ciro, Ferra, F, DI SALVO, E, DI MAIO M, GRIDELLI C, GALLO C, MANZIONE L, BRANCACCIO L, BARBERA S, ROBBIATI SF, IANNIELLO GP, FERRA F, PIAZZA E, FRONTINI L, ROSETTI F, CARROZZA F, BEARZ A, SPATAFORA M, ADAMO V, ISA L, IAFFAIOIL V, DI SALVO E, PERRONE F |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male cancer pain Cancer Research medicine.medical_specialty Lung Neoplasms Analgesic Pain Bone Neoplasms Severity of Illness Index law.invention Clinical Pain Management Index Randomized controlled trial Quality of life law Carcinoma Non-Small-Cell Lung Internal medicine Epidemiology Severity of illness Prevalence medicine Humans Pain Management Aged Pain Measurement Randomized Controlled Trials as Topic Aged 80 and over business.industry Guideline analgesic Middle Aged Clinical trial lung cancer Italy Oncology analgesics Quality of Life Physical therapy Female business Cancer pain |
| Zdroj: | Scopus-Elsevier British Journal of Cancer Europe PubMed Central |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6601810 |
| Popis: | Pain is a highly distressing symptom for patients with advanced cancer. WHO analgesic ladder is widely accepted as a guideline for its treatment. Our aim was to describe pain prevalence among patients diagnosed with advanced non-small-cell lung cancer (NSCLC), impact of pain on quality of life (QoL) and adequacy of pain management. Data of 1021 Italian patients enrolled in three randomised trials of chemotherapy for NSCLC were pooled. QoL was assessed by EORTC QLQ-C30 and LC-13. Analgesic consumption during the 3 weeks following QoL assessment was recorded. Adequacy of pain management was evaluated by the Pain Management Index (PMI). Some pain was reported by 74% of patients (42% mild, 24% moderate and 7% severe); 50% stated pain was affecting daily activities (30% a little, 16% quite a bit, 336 very much). Bone metastases strongly affected presence of pain. Mean global QoL linearly decreased from 64.9 to 36.4 from patients without pain to those with severe pain (P < 0.001). According to PMI, 616 out of 752 patients reporting pain (82%) received inadequate analgesic treatment. Bone metastases were associated with improved adequacy and worst pain with reduced adequacy at multivariate analysis. In conclusion, pain is common in patients with advanced NSCLC, significantly affects QoL, and is frequently undertreated. We recommend that: (i) pain self-assessment should be part of oncological clinical practice; (ii) pain control should be a primary goal in clinical practice and in clinical trials; (iii) physicians should receive more training in pain management; (iv) analgesic treatment deserves greater attention in protocols of anticancer treatment. © 2004 Cancer Research UK. |
| Databáze: | OpenAIRE |
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