A flavonoid-based fluorescent test strip for sensitive and selective detection of a gaseous nerve agent simulant
| Autor: | Jiahao Wang, Yingying Huang, Chengjun Pan, Tianyi Qin, Kangning Zhu, Bin Liu, Lei Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Chemistry 010401 analytical chemistry Flavonoid 02 engineering and technology 021001 nanoscience & nanotechnology Oxime 01 natural sciences Biochemistry Fluorescence Combinatorial chemistry 0104 chemical sciences Analytical Chemistry Gas phase chemistry.chemical_compound PEG ratio medicine Environmental Chemistry 0210 nano-technology Volatility (chemistry) Spectroscopy Nerve agent medicine.drug |
| Zdroj: | Analytica Chimica Acta. 1076:125-130 |
| ISSN: | 0003-2670 |
| Popis: | Developing fluorescent sensors with ability of monitoring gaseous nerve agents in a sensitive and selective manner is of great importance due to the extreme toxicity and volatility of organophosphorus nerve agents. Herein we reported a novel oxime-modified flavonoid sensor and carefully investigated its sensing behavior towards nerve agent simulants, diethylchlorophosphate (DCP). In the presence of DCP, a remarkable fluorescence enhancement accompanied with emission color change could be observed by naked eyes in solution. The response time was less than 90 s and LOD value was calculated as 0.78 μmol/L in solution. The sensing mechanism could be ascribed to the specific reaction between halophosphate and hydroxyl group of oxime. Furthermore, sensor strips have been successfully constructed by using PEG as matrix with a simple preparation process, and also achieved the sensitive and selective detection of DCP vapor. These results in this study may provide important references for further design of dye-based sensor strips for detection of nerve agents both in solution and gas phase. |
| Databáze: | OpenAIRE |
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