Alleviation of salt-induced exacerbation of cardiac, renal, and visceral fat pathology in rats with metabolic syndrome by surgical removal of subcutaneous fat
| Autor: | Kiyoshi Aoyama, Shiho Nakano, Katsuhide Ikeda, Yuki Komatsu, Xixi Cui, Yumeno Kawai, Sao Ashikawa, Mamoru Yoneda, Kohzo Nagata |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Endocrinology Diabetes and Metabolism Subcutaneous Fat Adipose tissue White adipose tissue Intra-Abdominal Fat 030204 cardiovascular system & hematology Kidney Article Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal Medicine medicine Animals Humans Obesity lcsh:RC620-627 Metabolic Syndrome Rats Inbred Dahl Adiponectin business.industry Myocardium Sodium Dietary Diet Sodium-Restricted medicine.disease Rats Disease Models Animal lcsh:Nutritional diseases. Deficiency diseases Cardiovascular diseases 030104 developmental biology medicine.anatomical_structure Hypertension Hypertrophy Left Ventricular Insulin Resistance Metabolic syndrome Adipocyte hypertrophy business |
| Zdroj: | Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-14 (2020) Nutrition & Diabetes |
| ISSN: | 2044-4052 |
| DOI: | 10.1038/s41387-020-00132-1 |
| Popis: | Objectives Evidence suggests that visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) should be considered as distinct types of white fat. Although VAT plays a key role in metabolic syndrome (MetS), the role of subcutaneous adipose tissue (SAT) has been unclear. DahlS.Z-Leprfa/Leprfa (DS/obese) rats, an animal model of MetS, develop adipocyte hypertrophy and inflammation to similar extents in SAT and VAT. We have now investigated the effects of salt loading and SAT removal on cardiac, renal, and VAT pathology in DS/obese rats. Methods DS/obese rats were subjected to surgical removal of inguinal SAT or sham surgery at 8 weeks of age. They were provided with a 0.3% NaCl solution as drinking water or water alone for 4 weeks from 9 weeks of age. Results Salt loading exacerbated hypertension, insulin resistance, as well as left ventricular (LV) hypertrophy, inflammation, fibrosis, and diastolic dysfunction in DS/obese rats. It also reduced both SAT and VAT mass but aggravated inflammation only in VAT. Although SAT removal did not affect LV hypertrophy in salt-loaded DS/obese rats, it attenuated hypertension, insulin resistance, and LV injury as well as restored fat mass and alleviated inflammation and the downregulation of adiponectin gene expression in VAT. In addition, whereas salt loading worsened renal injury as well as upregulated the expression of renin–angiotensin-aldosterone system-related genes in the kidney, these effects were suppressed by removal of SAT. Conclusions SAT removal attenuated salt-induced exacerbation of MetS and LV and renal pathology in DS/obese rats. These beneficial effects of SAT removal are likely attributable, at least in part, to inhibition of both VAT and systemic inflammation. |
| Databáze: | OpenAIRE |
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