Micafungin versus liposomal amphotericin B for pediatric patients with invasive candidiasis: substudy of a randomized double-blind trial
| Autor: | Flavio, Queiroz-Telles, Eitan, Berezin, Guy, Leverger, Antonio, Freire, Annalie, van der Vyver, Tawee, Chotpitayasunondh, Josip, Konja, Heike, Diekmann-Berndt, Sonja, Koblinger, Andreas H, Groll, Antonio, Arrieta |
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| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Antifungal Agents Adolescent Lipoproteins Population law.invention symbols.namesake Echinocandins Lipopeptides Randomized controlled trial Double-Blind Method law Internal medicine Amphotericin B medicine Humans Adverse effect education Child Fisher's exact test Mycosis education.field_of_study business.industry Micafungin Candidiasis Infant Newborn Infant medicine.disease Surgery Discontinuation Infectious Diseases Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health symbols business Infant Premature medicine.drug |
| Zdroj: | The Pediatric infectious disease journal. 27(9) |
| ISSN: | 0891-3668 |
| Popis: | Background: Invasive candidiasis is increasingly prevalent in premature infants and seriously ill children, and pediatric data on available antifungal therapies are lacking. Methods: We conducted a pediatric substudy as part of a double-blind, randomized, multinational trial to compare micafungin (2 mg/kg) with liposomal amphotericin B (3 mg/kg) as first-line treatment of invasive candidiasis. Treatment success was defined as clinical and mycologic response at the end of therapy. Statistical analyses were descriptive, as the sample size meant that the study was not powered for hypothesis testing. Results: One hundred six patients were included in the intent-to-treat population; and 98 patients-48 patients in the micafungin group and 50 patients in the liposomal amphotericin B group-in the modified intent-to-treat population. Baseline characteristics were balanced between treatment groups. Overall, 57 patients were |
| Databáze: | OpenAIRE |
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