The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia
| Autor: | Yu. I. Kirova, L. D. Luk'yanova, E. L. Germanova |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cell signaling Body resistance Citric Acid Cycle Succinic Acid Altitude Sickness General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine Animals Transcription factor gamma-Aminobutyric Acid Cerebral Cortex GABA shunt Electron Transport Complex I Chemistry Electron Transport Complex II Brain cortex Rats Inbred Strains General Medicine Oxygen deficiency Hypoxia (medical) Hypoxia-Inducible Factor 1 alpha Subunit Adaptation Physiological Rats Semicarbazides Cell biology Succinate Dehydrogenase High resistance Disease Models Animal 030104 developmental biology Gene Expression Regulation Phenobarbital Picolines medicine.symptom 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 164:298-303 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-3976-2 |
| Popis: | Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia. |
| Databáze: | OpenAIRE |
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