In vitro analysis of a physiological strain sensor formulated from a PEDOT:PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite
| Autor: | James Britton, Anup Poudel, Yina Guo, Catalina Vallejo-Giraldo, Marc A. Fernandez-Yague, Katarzyna Krukiewicz, Ghazal Tadayyon, Aitor Larrañaga, Manus J.P. Biggs, Gemma Orpella-Aceret, Lu Li |
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| Přispěvatelé: | SFI, ERDF, European Union (EU) |
| Rok vydání: | 2020 |
| Předmět: |
Glycerol
Materials science strain sensor Polymers Composite number Bioengineering 02 engineering and technology Carbon nanotube 010402 general chemistry Elastomer 01 natural sciences Urethane law.invention Biomaterials Polystyrene sulfonate chemistry.chemical_compound PEDOT:PSS law medicine PEDOT carbon nanotubes Nanotubes Carbon biodegradable polymer Biodegradation 021001 nanoscience & nanotechnology Bridged Bicyclo Compounds Heterocyclic Biodegradable polymer 0104 chemical sciences chemistry Chemical engineering Mechanics of Materials Swelling medicine.symptom 0210 nano-technology poly(glycerol sebacate urethane) |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 121 |
| ISSN: | 1873-0191 |
| Popis: | peer-reviewed Biodegradable strain sensors able to undergo controlled degradation following implantation have recently received significant interest as novel approaches to detect pathological tissue swelling or non-physiological stresses. In this study, the physicomechanical, electrochemical and active pressure sensing behavior of an electrically conductive and biodegradable poly(glycerol sebacate urethane) (PGSU) composite, reinforced with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) functionalized carbon nanotubes (CNTs), was evaluated in vitro. Analysis of these PGSU-CNTs composites demonstrated that the incorporation of functionalized CNTs into a biodegradable elastomer resulted in enhanced mechanical strength, conductivity and tailored matrix biodegradation. PGSU-CNT composites were subsequently formulated into flexible and active pressure sensors which demonstrated optimal sensitivity to applied 1% uniaxial tensile strains. Finally, cytocompatibility analysis a with primary neural culture confirmed that PGSU-CNT composites exhibited low cytotoxicity, and supported neuron adhesion, viability, and proliferation in vitro. |
| Databáze: | OpenAIRE |
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