Monitoring Disease Activity in Patients with Aortitis and Chronic Periaortitis Undergoing Immunosuppressive Therapy by Perfusion CT
| Autor: | Georg Bier, Heike Preibsch, Jörg Henes, Theodoros Xenitidis, Mustafa Kurucay, Konstantin Nikolaou, Marius Horger |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Perfusion Imaging Contrast Media Blood volume Perfusion scanning Blood Sedimentation Retroperitoneal fibrosis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Aortitis Aged Retrospective Studies 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Hemodynamics Patient Acuity Retroperitoneal Fibrosis Blood flow Middle Aged Image Enhancement medicine.disease C-Reactive Protein Erythrocyte sedimentation rate Female Radiology Drug Monitoring medicine.symptom Tomography X-Ray Computed Nuclear medicine business Perfusion Immunosuppressive Agents Tomography Emission-Computed |
| Zdroj: | Academic Radiology. 24:470-477 |
| ISSN: | 1076-6332 |
| DOI: | 10.1016/j.acra.2016.10.013 |
| Popis: | Rationale and Objectives To evaluate the role of perfusion CT for monitoring inflammatory activity in patients with aortitis and chronic periaortitis undergoing immunosuppressive therapy. Materials and Methods Seventeen symptomatic patients (median age 68.5 years) who underwent perfusion-based computed tomography (CT) monitoring after diagnostic contrast-enhanced CT were retrospectively included in this study. Blood flow (BF), blood volume (BV), volume transfer constant (k-trans), time to peak, and mean transit time were determined by setting circular regions of interest in prominently thickened parts of the vessel wall or perfused surrounding tissue at sites where the perfusion CT color maps showed a maximum BF value. Differences in CT perfusion and, morphological parameters, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were tested for significance during therapy. Results In all patients BF and BV dropped at second perfusion CT (P |
| Databáze: | OpenAIRE |
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