Effects of oral contraceptives on fibrinoiytic response to exercise
| Autor: | M. A. Martín-Nuño, José G. Villa, Javier González-Gallego, De Paz Ja, E. Vilades, J. Lasierra |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment media_common.quotation_subject Physical Therapy Sports Therapy and Rehabilitation Physical exercise Tissue plasminogen activator Fibrin Fibrinogen Degradation Products Internal medicine Fibrinolysis medicine Humans Orthopedics and Sports Medicine Levonorgestrel Exercise Menstrual cycle media_common business.industry T-plasminogen activator medicine.disease Hyperfibrinolysis Endocrinology Case-Control Studies Tissue Plasminogen Activator Female business Plasminogen activator Contraceptives Oral medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0195-9131 |
| DOI: | 10.1249/00005768-199507000-00003 |
| Popis: | The influence of low-dose oral contraceptives (OCs) on the different components of the fibrinolytic system was examined before and after maximum exercise in a group of 18 moderately active women. The group of OC users consisted of 9 women aged 21-33 years who had been using OCs for at least 6 months prior to the study. 5 women used OCs containing 35 mcg of ethinyl estradiol (EE) and 75 mcg of levonorgestrel (LNG); 4 women used OCs containing 30 mcg of EE and 150 mcg of LNG. The 9 controls aged 18-29 had not been on OC medication for more than 12 months. Both groups performed a maximal effort treadmill protocol between days 20 and 24 of the menstrual cycle. Comparison of the resting parameters revealed higher plasma fibrin degradation products (FbDP) plasminogen alpha2-antiplasmin and protein C concentrations and lower plasminogen activator inhibitor (PAI) activity in the OC group. No differences were observed in plasma concentrations of tissue plasminogen activator (t-PA) antigen t-PA activity t-PA/PAI complexes and FbDP in both groups of subjects while PAI activity was reduced. No significant differences were found for the change in these parameters between controls and OC users. Postexercise PAI activity was reduced both in controls and OC users but no significant difference was found for the change detected between the two groups. Exercise induced no variation in either of the groups for PAI antigen alpha2-plasmin plasminogen protein C or protein S. These data confirm that increased t-PA release is an important mediator in exercise-induced hyperfibrinolysis and they suggest that changes in the fibrinolytic system induced by physical exercise are not affected by OCs. |
| Databáze: | OpenAIRE |
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