Applicability of modified Glasgow Prognostic Score in the assessment of elderly patients with cancer: A pilot study
| Autor: | Viviane Lealdini, Damila Cristina Trufelli, Leandro Luongo de Matos, Savia Raquel Costa Normando, Fernando Luiz Affonso Fonseca, Auro Del Giglio, Patricia Xavier Santi, Elisa Watanabe Camargo, Fernanda Borges Ferreira da Silva |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Frail Elderly Pilot Projects Disease Severity of Illness Index Internal medicine Neoplasms Surveys and Questionnaires Severity of illness medicine Humans Stage (cooking) Neoplasm Metastasis Geriatric Assessment Serum Albumin Aged Aged 80 and over Inflammation Performance status biology business.industry C-reactive protein Cancer medicine.disease Prognosis Surgery C-Reactive Protein Oncology Localized disease biology.protein Female Sample collection Geriatrics and Gerontology business Brazil |
| Zdroj: | Journal of geriatric oncology. 6(6) |
| ISSN: | 1879-4076 |
| Popis: | Objectives To evaluate the relationship between inflammatory parameters through the modified Glasgow Prognostic Score (mGPS) and other clinical characteristics of elderly patients with cancer, including frailty evaluated by the Edmonton Frailty Scale (EFS). Materials and Methods We included patients from the oncology service at Faculdade de Medicina do ABC with a confirmed diagnosis of solid tumor aged 65 years or more at diagnosis. Patients were assessed by applying the translated and validated to Portuguese version of the EFS and also had blood sample collection for the evaluation of C-reactive protein (CRP) and albumin for calculation of the mGPS. Results We included 52 patients of both sexes, with median age of 72.5 years, of these 67.3% had localized disease and 32.7% metastatic disease. The mGPS presented 17.3% of high-risk patients. The frailty evaluated by EFS occurred in 57.6% of patients. Patients with both abnormal parameters (CRP and albumin) in the mGPS had significantly higher scores on EFS when compared to those with no change (6 vs. 9.56 points, p = 0.021). The mGPS correlated also with clinical staging (p = 0.019) and performance status (p = 0.039). Conclusions Inflammatory parameters correlate significantly with frailty, more advanced clinical stage and poor functional status. |
| Databáze: | OpenAIRE |
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