Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration

Autor: Limei Li, Yi Deng, Xueqi Gan, Hao Wang, Xidan Zhang, Jiyu Sun, Jiacheng Shi, Qiuyang Han, Xinliang Fu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Polymers
Surface Properties
General Chemical Engineering
Science
General Physics and Astronomy
Medicine (miscellaneous)
Matrix metalloproteinase
Biochemistry
Genetics and Molecular Biology (miscellaneous)
Mitochondrial Dynamics
Osseointegration
Bone remodeling
Polyethylene Glycols
Benzophenones
In vivo
Osteogenesis
Diabetes mellitus
medicine
Diabetes Mellitus
nutrient element
Animals
Humans
General Materials Science
Tibia
Femur
Research Articles
chemistry.chemical_classification
Membrane Potential
Mitochondrial
Reactive oxygen species
Osteoblasts
polyetheretherketone
General Engineering
Nutrients
Prostheses and Implants
medicine.disease
orthopedic implant
Cell biology
Mitochondria
Rats
Disease Models
Animal
chemistry
Hyperglycemia
Liberation
Zinc Oxide
Reactive Oxygen Species
Research Article
Zdroj: Advanced Science
Advanced Science, Vol 8, Iss 20, Pp n/a-n/a (2021)
ISSN: 2198-3844
Popis: As a chronic metabolic disease, diabetes mellitus (DM) creates a hyperglycemic micromilieu around implants, resulting inthe high complication and failure rate of implantation because of mitochondrial dysfunction in hyperglycemia. To address the daunting issue, the authors innovatively devised and developed mitochondria‐targeted orthopedic implants consisted of nutrient element coatings and polyetheretherketone (PEEK). Dual nutrient elements, in the modality of ZnO and Sr(OH)2, are assembled onto the sulfonated PEEK surface (Zn&Sr‐SPEEK). The results indicate the synergistic liberation of Zn2+ and Sr2+ from coating massacres pathogenic bacteria and dramatically facilitates cyto‐activity of osteoblasts upon the hyperglycemic niche. Intriguingly, Zn&Sr‐SPEEK implants are demonstrated to have a robust ability to recuperate hyperglycemia‐induced mitochondrial dynamic disequilibrium and dysfunction by means of Dynamin‐related protein 1 (Drp1) gene down‐regulation, mitochondrial membrane potential (MMP) resurgence, and reactive oxygen species (ROS) elimination, ultimately enhancing osteogenicity of osteoblasts. In vivo evaluations utilizing diabetic rat femoral/tibia defect model at 4 and 8 weeks further confirm that nutrient element coatings substantially augment bone remodeling and osseointegration. Altogether, this study not only reveals the importance of Zn2+ and Sr2+ modulation on mitochondrial dynamics that contributes to bone formation and osseointegration, but also provides a novel orthopedic implant for diabetic patients with mitochondrial modulation capability.
The synthesized dual nutrient element decorated implants enable to inhibit the overexpression of Drp1 gene, eliminate accumulated ROS of cells, recuperate MMP, ultimately contributing to regulating mitochondrial dynamics and functions, thereby enhancing osteogenicity of osteoblasts in hyperglycemia, which hold considerable promise for the future design of mitochondria‐targeted pathological implants.
Databáze: OpenAIRE
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