Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration
Autor: | Limei Li, Yi Deng, Xueqi Gan, Hao Wang, Xidan Zhang, Jiyu Sun, Jiacheng Shi, Qiuyang Han, Xinliang Fu |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Polymers
Surface Properties General Chemical Engineering Science General Physics and Astronomy Medicine (miscellaneous) Matrix metalloproteinase Biochemistry Genetics and Molecular Biology (miscellaneous) Mitochondrial Dynamics Osseointegration Bone remodeling Polyethylene Glycols Benzophenones In vivo Osteogenesis Diabetes mellitus medicine Diabetes Mellitus nutrient element Animals Humans General Materials Science Tibia Femur Research Articles chemistry.chemical_classification Membrane Potential Mitochondrial Reactive oxygen species Osteoblasts polyetheretherketone General Engineering Nutrients Prostheses and Implants medicine.disease orthopedic implant Cell biology Mitochondria Rats Disease Models Animal chemistry Hyperglycemia Liberation Zinc Oxide Reactive Oxygen Species Research Article |
Zdroj: | Advanced Science Advanced Science, Vol 8, Iss 20, Pp n/a-n/a (2021) |
ISSN: | 2198-3844 |
Popis: | As a chronic metabolic disease, diabetes mellitus (DM) creates a hyperglycemic micromilieu around implants, resulting inthe high complication and failure rate of implantation because of mitochondrial dysfunction in hyperglycemia. To address the daunting issue, the authors innovatively devised and developed mitochondria‐targeted orthopedic implants consisted of nutrient element coatings and polyetheretherketone (PEEK). Dual nutrient elements, in the modality of ZnO and Sr(OH)2, are assembled onto the sulfonated PEEK surface (Zn&Sr‐SPEEK). The results indicate the synergistic liberation of Zn2+ and Sr2+ from coating massacres pathogenic bacteria and dramatically facilitates cyto‐activity of osteoblasts upon the hyperglycemic niche. Intriguingly, Zn&Sr‐SPEEK implants are demonstrated to have a robust ability to recuperate hyperglycemia‐induced mitochondrial dynamic disequilibrium and dysfunction by means of Dynamin‐related protein 1 (Drp1) gene down‐regulation, mitochondrial membrane potential (MMP) resurgence, and reactive oxygen species (ROS) elimination, ultimately enhancing osteogenicity of osteoblasts. In vivo evaluations utilizing diabetic rat femoral/tibia defect model at 4 and 8 weeks further confirm that nutrient element coatings substantially augment bone remodeling and osseointegration. Altogether, this study not only reveals the importance of Zn2+ and Sr2+ modulation on mitochondrial dynamics that contributes to bone formation and osseointegration, but also provides a novel orthopedic implant for diabetic patients with mitochondrial modulation capability. The synthesized dual nutrient element decorated implants enable to inhibit the overexpression of Drp1 gene, eliminate accumulated ROS of cells, recuperate MMP, ultimately contributing to regulating mitochondrial dynamics and functions, thereby enhancing osteogenicity of osteoblasts in hyperglycemia, which hold considerable promise for the future design of mitochondria‐targeted pathological implants. |
Databáze: | OpenAIRE |
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