Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles
| Autor: | Il Je Yu, KiSoo Jeon, Ki-Joon Jeon, Hee-Jung Kim, Jae-Seong Yi |
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| Rok vydání: | 2019 |
| Předmět: |
Inhalation exposure
Inhalation Exposure Chromatography Materials science Inhalation General Immunology and Microbiology General Chemical Engineering General Neuroscience Nose Organic vapor General Biochemistry Genetics and Molecular Biology Toxicity Administration Inhalation Toxicity Tests Test chamber Animals Nanoparticles Particle size Particle Size Nano sized Rheology Nose only inhalation |
| Zdroj: | Journal of visualized experiments : JoVE. (145) |
| ISSN: | 1940-087X |
| Popis: | Using a numerical analysis based on computerized fluid dynamics, a nose-only inhalation toxicity chamber with four different exposure concentrations is designed and validated for flow field uniformity and cross-contamination among the exposure ports for each concentration. The designed flow field values are compared with the measured values from exposure ports located horizontally and vertically. For this purpose, nanoscale sodium chloride particles are generated as test particles and introduced to the inhalation chamber to evaluate the cross-contamination and concentration maintenance among the chambers, for each concentration group. The results indicate that the designed multiconcentration inhalation chamber can be used in animal inhalation toxicity testing without cross-contamination among concentration groups. Moreover, the designed multiconcentration inhalation toxicity chamber can also be converted to a single-concentration inhalation chamber. Further testing with gas, organic vapor, or non-nanoscale particles will ensure the use of the chamber in the inhalation testing of other test articles. |
| Databáze: | OpenAIRE |
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