Extract of Oxytropis pseudoglandulosa inhibits vascular smooth muscle cell proliferation and migration via suppression of ERK1/2 and Akt signaling pathways1
| Autor: | Jiyun Lee, Sangho Choi, Hyang-Hee Seo, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang, Chang Youn Lee, Badamtsetseg Bazarragchaa, Gantuya Batdelger |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vascular smooth muscle MAP Kinase Signaling System Physiology Cell Biology Muscle Smooth Vascular Oxytropis Rats Sprague-Dawley 03 medical and health sciences Cell Movement In vivo Physiology (medical) medicine Animals Cytotoxic T cell Occlusive vascular disease Protein kinase B Cell Proliferation Cell growth Hematology musculoskeletal system biology.organism_classification Rats 030104 developmental biology medicine.anatomical_structure cardiovascular system Cancer research Cardiology and Cardiovascular Medicine Proto-Oncogene Proteins c-akt |
| Zdroj: | Clinical Hemorheology and Microcirculation. 69:277-287 |
| ISSN: | 1875-8622 1386-0291 |
| DOI: | 10.3233/ch-189126 |
| Popis: | Excessive vascular smooth muscle cell (VSMC) proliferation and migration accelerate the development of occlusive vascular disease. Therefore, finding a means to control the aberrant proliferation and migration of VSMCs has own clinical significance. In the present study, we examined the feasibility of using extract from medicinal plant Oxytropis pseudoglandulosa (OG) to control pathologic proliferation and migration of VSMCs, which never have been tested. Our data indicate that the extract of OG significantly suppressed proliferation and migration of VSMCs without cytotoxic effect, suggesting the OG extract may be an alternative agent to effectively control the aberrant VSMC proliferation and migration without any serious adverse effect. These data suggest that the extract of OG may be a potent therapeutic agent for the treatment of occlusive vascular disease and warrant further studies to identify the major acting ingredient and to validate in vivo efficacy. |
| Databáze: | OpenAIRE |
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