Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host
| Autor: | Daria Tashyreva, Anna I. Ganyukova, Martina Tesařová, Claudia M. d’Avila-Levy, Diego H. Macedo, Jana Režnarová, Alexei Y. Kostygov, Alexander O. Frolov, Lyudmila V. Chistyakova, Viktoria V. Spodareva, Marina N. Malysheva, Anzhelika Butenko, Julius Lukeš, Vyacheslav Yurchenko |
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| Rok vydání: | 2020 |
| Předmět: |
Flagella connector
0106 biological sciences Tsetse Flies Cell division Physiology media_common.quotation_subject Motility Plant Science Insect Cell cycle Flagellum Biology Trypanosoma brucei 010603 evolutionary biology 01 natural sciences General Biochemistry Genetics and Molecular Biology Host-Parasite Interactions 03 medical and health sciences Structural Biology Animals Herpetomonas muscarum ingenoplastis lcsh:QH301-705.5 Ecology Evolution Behavior and Systematics 030304 developmental biology media_common 0303 health sciences Host (biology) fungi Midgut Cell Biology biology.organism_classification Cell biology lcsh:Biology (General) Flagella Trypanosomatina Peristalsis General Agricultural and Biological Sciences Cytokinesis Research Article Developmental Biology Biotechnology |
| Zdroj: | BMC Biology BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020) |
| ISSN: | 1741-7007 |
| Popis: | Background The family Trypanosomatidae encompasses parasitic flagellates, some of which cause serious vector-transmitted diseases of humans and domestic animals. However, insect-restricted parasites represent the ancestral and most diverse group within the family. They display a range of unusual features and their study can provide insights into the biology of human pathogens. Here we describe Vickermania, a new genus of fly midgut-dwelling parasites that bear two flagella in contrast to other trypanosomatids, which are unambiguously uniflagellate. Results Vickermania has an odd cell cycle, in which shortly after the division the uniflagellate cell starts growing a new flagellum attached to the old one and preserves their contact until the late cytokinesis. The flagella connect to each other throughout their whole length and carry a peculiar seizing structure with a paddle-like apex and two lateral extensions at their tip. In contrast to typical trypanosomatids, which attach to the insect host’s intestinal wall, Vickermania is separated from it by a continuous peritrophic membrane and resides freely in the fly midgut lumen. Conclusions We propose that Vickermania developed a survival strategy that relies on constant movement preventing discharge from the host gut due to intestinal peristalsis. Since these parasites cannot attach to the midgut wall, they were forced to shorten the period of impaired motility when two separate flagella in dividing cells interfere with each other. The connection between the flagella ensures their coordinate movement until the separation of the daughter cells. We propose that Trypanosoma brucei, a severe human pathogen, during its development in the tsetse fly midgut faces the same conditions and follows the same strategy as Vickermania by employing an analogous adaptation, the flagellar connector. |
| Databáze: | OpenAIRE |
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