Polymer hydration and stiffness at biointerfaces and related cellular processes
| Autor: | Garry Kerch |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Polymers Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering Nanotechnology Biointerface 02 engineering and technology 010402 general chemistry 01 natural sciences Viscoelasticity Cell Physiological Phenomena Surface stiffness medicine Substrate stiffness Animals Humans General Materials Science chemistry.chemical_classification Dehydration Stiffness Prostheses and Implants Adhesion Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Biophysics Molecular Medicine medicine.symptom 0210 nano-technology Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Nanomedicine: Nanotechnology, Biology and Medicine. 14:13-25 |
| ISSN: | 1549-9634 |
| Popis: | The direct and indirect (by changing mechanical properties) effects of hydration at interfaces on cellular processes and tissue diseases are reviewed. The essential effect of substrate stiffness on cellular processes was demonstrated in the last decade. The combined effect of surface stiffness and hydration at interfaces has garnered much less attention, though hydration and dehydration play important roles in biological processes. This review focuses on the studies that demonstrate how hydration affects biological processes at interfaces. Elevated sodium and dehydration stimulate inflammatory signaling in endothelial cells and promote atherosclerosis. Various types of implant and blood contacting device coatings with varied surface stiffness and hydration have been reported. Effect of hydration on polymer modulus of elasticity and viscoelasticity was discussed taking into account cells adhesion, migration, proliferation, differentiation on surfaces with various degree of hydration. Future directions of research were considered, including the use of nanotechnology to regulate the hydration degree. |
| Databáze: | OpenAIRE |
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