Blockade of signaling via the very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) causes increased T cell apoptosis in experimental autoimmune neuritis
| Autor: | Ralf Gold, Leussink Vi, Pepinsky Rb, K.V. Toyka, Guido Stoll, Uwe K. Zettl, Lobb Rr, Sebastian Jander |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Integrins
medicine.medical_specialty Adoptive cell transfer Time Factors T-Lymphocytes Receptors Lymphocyte Homing Vascular Cell Adhesion Molecule-1 Apoptosis Integrin alpha4beta1 Pathology and Forensic Medicine Cellular and Molecular Neuroscience chemistry.chemical_compound Antigen Internal medicine Anti-Allergic Agents medicine Animals VCAM-1 Cell adhesion biology Cell adhesion molecule T lymphocyte Neuritis Autoimmune Experimental Rats Nitric oxide synthase Disease Models Animal Endocrinology chemistry Rats Inbred Lew Disease Progression biology.protein Cancer research Female Neurology (clinical) Signal Transduction |
| Zdroj: | Acta Neuropathologica. 103:131-136 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/s004010100444 |
| Popis: | We characterized the early effects of anti-very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) antibody therapy on T cell infiltration and apoptosis in adoptive transfer experimental autoimmune neuritis of female Lewis rats. At the peak of disease, animals were treated with anti-VCAM-1 monoclonal antibody (mAb), anti-VLA-4 mAb, or the respective isotype mAb controls 18, 12, or 6 h before perfusion. Anti-VCAM-1 led to a rapid, significant increase of apoptotic T cells in the sciatic nerve with a maximum after 6 h, preceding the significant decrease of T cell infiltration seen after 18 h. This was accompanied by a significant reduction in mRNA levels for IFN-gamma and inducible nitric oxide synthase. The results for anti-VLA-4 treatment showed a similar trend. The early increase of T cell apoptosis following disruption of VLA-4/VCAM-1 interaction may reflect a novel signaling component of proapoptotic pathways. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink