Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity
| Autor: | Clifford A. Lingwood, Patty Tam, Aye Aye Khine, Anita Nutikka |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Cytoplasm
Endosome Cell Survival Caveolin 1 Golgi Apparatus Biology Shiga Toxin 1 Biochemistry Filipin Caveolins symbols.namesake chemistry.chemical_compound Chlorocebus aethiops Animals Vero Cells Brefeldin A Cell Death Endoplasmic reticulum Trihexosylceramides Golgi Targeting Golgi apparatus Cell biology Protein Transport chemistry Protein Biosynthesis symbols Vero cell Intracellular |
| Zdroj: | Glycobiology. 14(8) |
| ISSN: | 0959-6658 |
| Popis: | In verotoxin 1 (VT1)-sensitive cells, globotriaosyl ceramide (Gb 3 ) bound VT1 is endocytosed and transported retrogradely to the Golgi/endoplasmic reticulum (ER). The importance of the Golgi-dependent retrograde transportof VT1 is now shown to vary as a function of both VT1 exposure time and concentration. Following 3 h exposure to |
| Databáze: | OpenAIRE |
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