Photophysical Exploration of Zn(II) Polypyridine Photosensitizers in Two-Photon Photodynamic Therapy: Insights from Theory

Autor:	Xue Wei, Xue-Hui Guo, Jing-Fu Guo, Teng-Fei He, Gui-Ya Qin, Lu-Yi Zou, Ai-Min Ren
Rok vydání:	2022
Předmět:	Inorganic Chemistry Zinc Photosensitizing Agents Photochemotherapy Coordination Complexes Physical and Theoretical Chemistry Ligands
Zdroj:	Inorganic Chemistry. 61:18729-18742
ISSN:	1520-510X 0020-1669
DOI:	10.1021/acs.inorgchem.2c03232
Popis:	The high incidence and difficulties of treatment of cancer have always been a challenge for mankind. Two-photon photodynamic therapy (TP-PDT) as a less invasive technique provides a new perspective for tumor treatment due to its low-energy near-infrared excitation, high targeting, and minor damage. At present, the emerging metal complexes used as the photosensitizers (PSs) in TP-PDT have aroused great interest. However, most metal complexes as PSs in TP-PDT still face some problems, such as slow clearance, unsatisfactory two-photon absorption (TPA) characteristics, high price, low reactivity, and poor solubility. In this work, density functional theory and time-dependent density functional theory were used to characterize the one/two-photon response, solvation free energy, and lipophilicity of a series of novel PSs applied in TP-PDT. The results suggest that based on complex
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08548d0a3ca6d9801dff99078d2402e0 https://doi.org/10.1021/acs.inorgchem.2c03232 Zobrazit plný text záznamu