Preoperative neutrophil-to-lymphocyte ratio as a predictive factor for survival in nonmetastatic colorectal cancer

Autor:	Bahadır Öndeş, Osman Uyar, Sevim Turanli, Onur Can Güler, Uğur Berberoğlu, Kaptan Gülben
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty Multivariate analysis Colorectal cancer Lymphovascular invasion Neutrophils Gastroenterology Internal medicine medicine Biomarkers Tumor Humans Radiology Nuclear Medicine and imaging Lymphocytes Neutrophil to lymphocyte ratio Pathological Retrospective Studies Receiver operating characteristic business.industry fungi Hazard ratio General Medicine Middle Aged medicine.disease Prognosis Confidence interval Survival Rate Oncology ROC Curve Female business Colorectal Neoplasms Colorectal Surgery Follow-Up Studies
Zdroj:	Journal of cancer research and therapeutics. 16
ISSN:	1998-4138
Popis:	Background The pretreatment ratio of neutrophils to lymphocytes (NLR) has been suggested as an indicator of poor outcome in various cancers. This study aimed to determine whether the preoperative NLR may be a predictor of survival in patients who underwent curative resection for colorectal cancer (CRC). Materials and methods The records of 219 CRC patients underwent curative resection between 2008 and 2014 were retrospectively evaluated. NLR was calculated by preoperative complete blood counts. The effects of age, gender, anatomic location, histologic grade, lymphovascular invasion, pathological T, pathological N, and tumor-node-metastasis stages and NLR on disease-free survival (DFS) and overall survival (OS) were analyzed using univariate and multivariate analyses. The optimal cutoff value for NLR was determined using receiver operating characteristic curve analysis. Results The best cutoff value of NLR was 2.8. Multivariate analysis showed that NLR was not a predictor of DFS. However, NLR was found as an independent prognostic factor for OS (Hazard ratio, 5.4; 95% confidence interval, 2.3-12.5; P = 0.0001). Conclusion A preoperative NLR of more than 2.8 might be an independent predictor for OS in patients with CRC. This simple and routinely available laboratory parameter may be used as a useful marker for identifying patients with a worse prognosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08526cc3d3ae37b157875cad2cc7ff4c https://pubmed.ncbi.nlm.nih.gov/33380676 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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