Δ8(14)-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase
| Autor: | Dowon Yoon, Hakwon Kim, Yujin Park, Tae Hoon Lee, Myoungsil Ko, Eunjoohwang Lee, Jeonguk Kim, Hye-Jin Moon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Interleukin-1beta
Anti-Inflammatory Agents Nitric Oxide Synthase Type II Pharmaceutical Science Arthritis Organic chemistry Pharmacology Matrix metalloproteinase Analytical Chemistry chemistry.chemical_compound 0302 clinical medicine QD241-441 Ergosterol Drug Discovery Glycosides chemistry.chemical_classification 0303 health sciences Communication collagen type II A1 Synoviocytes ergostenol arthritis Chemistry (miscellaneous) Molecular Medicine medicine.symptom Signal Transduction matrix metalloproteinase Cell Survival Inflammation Chronic inflammatory disease Models Biological Cell Line 03 medical and health sciences Chondrocytes medicine Humans ergostenol glycosides Physical and Theoretical Chemistry Collagen Type II 030304 developmental biology 030203 arthritis & rheumatology Collagen type Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-8 Glycoside medicine.disease Matrix Metalloproteinases Sterol Spinasterol Gene Expression Regulation chemistry |
| Zdroj: | Molecules, Vol 26, Iss 4547, p 4547 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective treatments to alleviate the inflammation of arthritis with fewer side-effects. In this study, a new sterol, Δ8(14)-ergostenol, was discovered, and its glycosides were synthesized and found to be more efficient in terms of synthesis or anti-inflammatory activity than either spinasterol or 5,6-dihydroergosterol is. Among these synthetic glycosides, galactosyl ergostenol inhibited the expression of inflammatory mediators in TNF-α-stimulated FLS and TNF-α-induced MMPs and collagen type II A1 degradation in human chondrocytes. These results suggest the new galactosyl ergostenol as a treatment candidate for arthritis. |
| Databáze: | OpenAIRE |
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