CADASIL and migraine: A narrative review
| Autor: | Joost Haan, Jeroen van der Grond, Michel D. Ferrari, Michael K. Liem, Saskia A J Lesnik Oberstein |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Receptors Notch Aura business.industry Migraine Disorders MEDLINE CADASIL General Medicine medicine.disease Migraine CADASIL aura spreading depression NOTCH3 autosomal-dominant arteriopathy cortical spreading depression brain-stem activation subcortical infarcts blood-flow white-matter vascular malformation cerebral hemodynamics notch3 mutation functional mri Disease susceptibility Migraine Cortical spreading depression Medicine Humans Narrative review Neurology (clinical) Disease Susceptibility business Psychiatry Receptor Notch3 |
| Zdroj: | Cephalalgia, 30(11), 1284-9 Cephalalgia, 30(11), 1284-1289 Cephalalgia |
| ISSN: | 1468-2982 |
| Popis: | Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene and is clinically characterized by recurrent stroke, cognitive decline, psychiatric disturbances and migraine. The prevalence of migraine in CADASIL is slightly higher than in the general population, and the proportion of migraine with aura is much higher. The pathophysiological mechanism that leads to increased aura prevalence in CADASIL is unknown. Possible mechanisms of the excess of migraine with aura are an increased susceptibility to cortical spreading depression (CSD) or a different expression of CSD. It is also possible that the brainstem migraine area is involved in CADASIL. Last, it is possible that the NOTCH3 mutation acts as a migraine aura susceptibility gene by itself. In this narrative review we summarize the literature about migraine in CADASIL, with a special focus on what CADASIL might teach us about the pathophysiology of migraine. PMID: 21038489 [PubMed - in process] |
| Databáze: | OpenAIRE |
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