Targeting 'diabetic' coronary artery disease merging the properties of sirolimus coated balloon with sirolimus eluting stent
| Autor: | Rashmit Pandya, Antonio Popolo Rubbio, Matteo Casenghi, Arvind Sharma, Pritesh Parekh, Sameer Dani, Devang Desai, Chirag Seth, Luca Testa, F. Bedogni, Nirav Bhalani |
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| Rok vydání: | 2021 |
| Předmět: |
Sirolimus
medicine.medical_specialty education.field_of_study business.industry medicine.medical_treatment Population Percutaneous coronary intervention Stent Drug-Eluting Stents Coronary Artery Disease medicine.disease Coronary artery disease Diabetes Mellitus Type 2 Drug-eluting stent Internal medicine medicine Clinical endpoint Cardiology Humans Myocardial infarction Prospective Studies Cardiology and Cardiovascular Medicine business education Mace |
| Zdroj: | Minerva cardiology and angiology. 69(5) |
| ISSN: | 2724-5772 |
| Popis: | BACKGROUND Patients with diabetes mellitus (DM) represents a challenging subset of population as they experience worse outcomes after percutaneous coronary intervention than patients without diabetes. We evaluated the 2-year efficacy and safety profile of the Abluminus DES+ in patients with diabetes within the population enrolled in the large multicenter en-ABL e-registry. METHODS Multicenter, prospective, all-comers registry performed in 31 centers in India. We analyze patients according to the diagnosis of DM and insulin dependency (ID or Non-ID): non-DM (1641 patients), NIDDM (721 patients), IDDM (138 patients). The primary endpoint was a composite of device-oriented major adverse cardiac events (MACE): cardiac death, target vessel-related myocardial infarction (MI), and ischemia-driven target lesion revascularization (TLR)/ target vessel revascularization (TVR) at 2-year. Stent thrombosis (ST) at any time point was also recorded. RESULTS The MACE rate at 2-year follow-up was 3.0% in the overall population with DM patients showing a higher rate of primary endpoint compared to non-DM (4.4% vs. 2.4%, P=0.025). Rate of cardiac death was actually low and consistent between the 2 groups (1.7% vs. 0.9%, P=0.100). At 2-year follow-up, the rate of ST was 0.9% in DM patients versus 0.5% in non-DM, P=0.213. CONCLUSIONS At 2-year follow-up, the Abluminus DES+ technology that merges the features of a sirolimus coated balloon with those of a bioresorbable polymer drug eluting stent appears to be safe and effective. This safety/efficacy profile was consistent in patients with or without DM. |
| Databáze: | OpenAIRE |
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